Набор скоро начнётся NCT07441265

Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?

Без фазы С лечением Circadian Misalignment Sex Differences

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Day shift, Night shift.
Кому может быть актуально: Состояния в реестре: Circadian Misalignment, Sex Differences. Базовые параметры: 18 лет — 40 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Role of Biological Sex in Metabolic Responses to Night Work

Обзор

This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger/fullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.

Подробное описание

This study will examine whether biological sex affects how the body responds to circadian misalignment-a mismatch between a person's internal body clock and their sleep/wake and eating schedule (similar to what can happen with night shift work, jet lag, or frequently changing sleep schedules). Researchers will measure how circadian misalignment influences appetite regulation (such as hunger and fullness) and glucose metabolism (how the body controls blood sugar), and whether these effects differ between females and males.

By identifying sex-specific responses to circadian misalignment, this research may help guide the development of safer, more personalized shift work schedules and targeted strategies to reduce metabolic health risks, with the goal of improving clinical care and reducing sex-related differences in metabolic disease risk.

Вмешательства

Поведенческое Day shift
Research participants will be assigned to day shift condition in which sleep-wake and meal schedules are aligned with the internal circadian system
Поведенческое Night shift
Research participants will be assigned to simulated night shift condition in which sleep-wake and meal schedules are misaligned with the internal circadian system

Первичные конечные точки

Difference in circulating leptin levels between Night Shift and Day Shift [Срок оценки: 24 hours]
Differences in Disposition index (DI) derived from identical test breakfast between Night Shift and Day Shift [Срок оценки: 3 hours]
Differences in self-rated cravings for hyperpalatable food during the wake period between Night Shift and Day Shift. [Срок оценки: 16 hours]

Критерии участия

Критерии включения

18-40 years of age
Body Mass Index 18.5-24.9 kg/m2
Non-smokers, no current tobacco or e-cigarette use
Healthy with no acute or chronic medical and psychiatric disorders
Sex assigned at birth consistent with reproductive anatomy at enrollment (per protocol definition)