Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Vitamin D Deficiency. Базовые параметры: 20 лет — 40 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Turkey (Türkiye)
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Investigation of Postural Stability and Load-Sensitive Neuromuscular Control Mechanisms in Vitamin D Deficiency
Обзор
This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults. The study will compare individuals with vitamin D deficiency and healthy controls. Participants will undergo a single-session evaluation including surface electromyography and postural stability assessments during standing tasks under different loading and vibration conditions. No invasive procedures, medications, or blood sampling will be performed. Previously obtained routine laboratory results will be used for vitamin D status. The study is designed to improve understanding of neuromuscular responses associated with vitamin D deficiency and to contribute to future rehabilitation strategies.
Подробное описание
This single-center observational study is designed to evaluate postural stability and load-sensitive neuromuscular control mechanisms in adults with vitamin D deficiency.
Participants will be divided into two groups based on their vitamin D status: individuals with vitamin D deficiency and healthy controls. Vitamin D levels will be determined using previously obtained routine laboratory test results. No additional blood sampling will be performed for this study.
All participants will undergo a standardized assessment protocol in a single session. Surface electromyography will be used to record muscle activity during standing tasks under different postural and loading conditions. Measurements will be performed during single-leg and double-leg stance, with and without vibration stimulation. The procedures are non-invasive and do not involve any pharmacological intervention.
Postural stability parameters and neuromuscular response variables will be analyzed and compared between groups. The primary objective is to identify potential differences in reflex modulation and postural control associated with vitamin D deficiency.
The study aims to provide objective data on neuromuscular adaptations related to vitamin D status and to support future research in rehabilitation and balance training.
Первичные конечные точки
- Postural Stability Parameters [Срок оценки: Single assessment session (baseline)]
Вторичные конечные точки (2)
- Neuromuscular Reflex and Muscle Activation Patterns [Срок оценки: Single assessment session (baseline)]
- Effect of Loading and Vibration on Postural Control [Срок оценки: Single assessment session (baseline)]
Критерии участия
Критерии включения
- Age 20 to 40 years.
- Ability to provide written informed consent.
- Vitamin D deficiency group: serum 25-hydroxyvitamin D level <10 ng/mL measured within the last 3 months (routine clinical testing).
- Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months.
- No use of vitamin D or calcium supplementation within the last 3 months.
Критерии исключения
- Known metabolic bone disease other than vitamin D deficiency.
- Neurological disorder (central or peripheral) or neuromuscular disease.
- History of lower-limb surgery, fracture, or prosthesis affecting standing balance.
- Vestibular disorder.
- BMI >30 kg/m2.
- Active malignancy.
- Severe psychiatric disorder.
- Skin condition preventing placement of surface EMG electrodes.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Случай-контроль
Центры проведения
Turkey (Türkiye) · 1 центр
- Istanbul Physical Medicine and Rehabilitation Training and Research Hospital — Istanbul
Публикации
- Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Turker KS. A new method to determine reflex latency induced by high rate stimulation of the nervous system. Front Hum Neurosci. 2014 Jul 18;8:536. doi: 10.3389/fnhum.2014.00536. eCollection 2014. PMID 25100978
Идентификаторы
NCT: NCT07435935 · OSTEOMALACIA-BMR-2026