Role of Arterial Spin Labelling Magnetic Resonance Prefusion in Grading of Pediatric Brain Tumors
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Pediatric Brain Tumors. Базовые параметры: 0 лет — 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Список центров уточняется — проверьте первичный протокол.
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
Role of Arterial Spin Labelling Magnetic Resonance Perfusion in The Grading of Pediatric Brain Tumors
Обзор
To evaluate the diagnostic performance of arterial spin labelling (ASL) magnetic resonance perfusion in preoperative grading of pediatric brain tumors.
Подробное описание
Pediatric brain tumors are one of the most common malignancies in children and represent a leading cause of cancer-related morbidity and mortality worldwide. Accurate preoperative tumor grading plays a pivotal role in determining treatment strategies, surgical planning, prognosis and long-term follow-up. Histopathological grading remains the reference standard; however, non-invasive imaging capable of predicting tumor grade preoperatively are increasingly sought to optimize patient management.
Conventional magnetic resonance imaging (MRI) provides excellent anatomical resolution and lesion localization; nevertheless, substantial overlap persists in morphological imaging features between low-grade and high-grade pediatric brain tumors. In children, contrast enhancement does not correlate with tumor grade, unlike the way it does in adults. Diffusion parameters overlap between benign and aggressive lesions as well, limiting the accuracy of conventional MRI in reliable tumor grading when used alone.
Advanced MRI techniques, particularly perfusion imaging, have emerged as valuable adjuncts for tumor characterization by evaluating tumor vascularity and microcirculation. Arterial spin labelling (ASL) is a non-contrast perfusion MRI technique that quantifies cerebral blood flow (CBF) using magnetically labeled arterial blood water as an endogenous tracer. This technique is especially advantageous in the pediatric population, as it eliminates exposure to gadolinium-based contrast agents and avoids ionizing radiation, aligning with current safety recommendations in children.
High-grade pediatric brain tumors typically demonstrate increased angiogenesis, microvascular proliferation and elevated perfusion compared with low-grade tumors. Recent studies have shown that ASL-derived perfusion parameters correlate with tumor grade and histopathological aggressiveness in pediatric brain tumors.
Despite growing evidence supporting its diagnostic value, arterial spin labelling (ASL) remains underutilized in routine clinical practice for pediatric brain tumor grading. Further prospective studies are required to validate its diagnostic performance and establish its role as a reliable non-invasive imaging biomarker.
Первичные конечные точки
- Evaluate the diagnostic value of arterial spin labelling (ASL) magnetic resonance perfusion in pre-operative grading of pediatric brain tumors [Срок оценки: preoperative]
Критерии участия
Критерии включения
- Pediatric patients aged 18 years or younger.
- Patients with radiological diagnosis of intracranial brain tumors.
Критерии исключения
- Patients who have received prior surgery, chemotherapy or radiotherapy for brain tumors.
- Patients with contraindications to magnetic resonance imaging (MRI) examination.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Список центров уточняется — проверьте первичный протокол.
Публикации
- Kong L, Chen H, Yang Y, Chen L. A meta-analysis of arterial spin labelling perfusion values for the prediction of glioma grade. Clin Radiol. 2017 Mar;72(3):255-261. doi: 10.1016/j.crad.2016.10.016. Epub 2016 Dec 6. PMID 27932251
- Morana G, Tortora D, Stagliano S, Nozza P, Mascelli S, Severino M, Piatelli G, Consales A, Lequin M, Garre ML, Rossi A. Pediatric astrocytic tumor grading: comparison between arterial spin labeling and dynamic susceptibility contrast MRI perfusion. Neuroradiology. 2018 Apr;60(4):437-446. doi: 10.1007/s00234-018-1992-6. Epub 2018 Feb 16. PMID 29453753
- Dangouloff-Ros V, Deroulers C, Foissac F, Badoual M, Shotar E, Grevent D, Calmon R, Pages M, Grill J, Dufour C, Blauwblomme T, Puget S, Zerah M, Sainte-Rose C, Brunelle F, Varlet P, Boddaert N. Arterial Spin Labeling to Predict Brain Tumor Grading in Children: Correlations between Histopathologic Vascular Density and Perfusion MR Imaging. Radiology. 2016 Nov;281(2):553-566. doi: 10.1148/radiol.201 PMID 27257950
- Furtner J, Schopf V, Schewzow K, Kasprian G, Weber M, Woitek R, Asenbaum U, Preusser M, Marosi C, Hainfellner JA, Widhalm G, Wolfsberger S, Prayer D. Arterial spin-labeling assessment of normalized vascular intratumoral signal intensity as a predictor of histologic grade of astrocytic neoplasms. AJNR Am J Neuroradiol. 2014 Mar;35(3):482-9. doi: 10.3174/ajnr.A3705. Epub 2013 Aug 14. PMID 23945226
- Yeom KW, Mitchell LA, Lober RM, Barnes PD, Vogel H, Fisher PG, Edwards MS. Arterial spin-labeled perfusion of pediatric brain tumors. AJNR Am J Neuroradiol. 2014 Feb;35(2):395-401. doi: 10.3174/ajnr.A3670. Epub 2013 Aug 1. PMID 23907239
Идентификаторы
NCT: NCT07427316 · ASLMRI