Набор скоро начнётся NCT07427069

Chronic Kidney Disease Associated Diet

— Наблюдательное Chronic Kidney Disease Periodontitis Diet, Food and Nutrition

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально: Состояния в реестре: Chronic Kidney Disease, Periodontitis, Diet, Food and Nutrition. Базовые параметры: 18 лет — 65 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Turkey (Türkiye)
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

The Role of Pro-Inflammatory Diet in Periodontal Tissue Destruction in Chronic Kidney Disease

Обзор

The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association. The main question it aims to answer is: Does a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease? Participants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.

Подробное описание

This observational study will aim to investigate the association between chronic kidney disease (CKD) and periodontitis, with a specific focus on the potential role of dietary inflammatory potential measured by the Dietary Inflammatory Index (DII). Adult participants diagnosed with CKD will be enrolled and their periodontal status will be evaluated using standard clinical parameters, including plaque index, probing depth, clinical attachment loss, and bleeding on probing. Dietary intake data will be collected through a validated food frequency questionnaire, and individual DII scores will be calculated to estimate the inflammatory potential of each participant's diet. The study will analyze whether higher dietary inflammatory load is associated with increased periodontal disease severity in individuals with CKD. Findings from this study are expected to contribute to a better understanding of the interplay between systemic disease, oral health, and modifiable lifestyle factors such as diet.

Первичные конечные точки

Dietary Inflammatory Index [Срок оценки: Day 1]

Вторичные конечные точки (5)

Clinical Periodontal Parameters (Plaque Index) [Срок оценки: Day 1]
Clinical Periodontal Parameters (Gingival Index) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Bleeding on Probing Index) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Probing Pocket Depth) [Срок оценки: Day 1]
Periodontal Clinical Parametres (Clinical Attachment Loss) [Срок оценки: Day 1]

Критерии участия

Критерии включения

Being between 18 and 65 years of age
Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml/min/1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg/g (proteinuria))
Having at least 20 teeth
Not having received periodontal therapy in the last 6 months
Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
Not having any autoimmune disease, osteoporosis, or cancer
Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates
Not being pregnant
Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
Not taking antioxidant supplements in the last 6 months