Older Kidney Patient Optimisation Pretransplant

Older adults with advanced chronic kidney disease (CKD) are increasingly being assessed for kidney transplantation. However, multimorbidity, frailty, and cognitive impairment are highly prevalent in this population and may influence transplant eligibility, perioperative risk, recovery trajectories, and longer-term outcomes. Current transplant assessment pathways are not routinely designed to systematically identify or address these geriatric syndromes.

Comprehensive Geriatric Assessment (CGA) is a structured, multidimensional process that evaluates medical, functional, cognitive, psychological, and social domains, with the aim of informing personalised care planning and optimisation. CGA has demonstrated benefit in older surgical and oncological populations, but its feasibility and impact within kidney transplant assessment pathways remain uncertain.

The OK-POP study is a single-centre, randomised controlled feasibility trial evaluating the integration of a kidney transplant-specific CGA (KT-CGA) into routine outpatient transplant assessment at Guy's and St Thomas' NHS Foundation Trust. Participants undergoing transplant assessment are randomised in a 1:1 ratio to either usual transplant assessment care or usual care supplemented by KT-CGA delivered by a clinician trained in geriatric principles.

The primary focus of the study is to assess the feasibility and acceptability of delivering KT-CGA within an established transplant assessment pathway. This includes evaluation of recruitment and retention processes, completeness of study assessments, fidelity of KT-CGA delivery, and acceptability to both patients and clinical staff.

Secondary objectives explore the clinical, service-level, and patient-centred consequences of KT-CGA, including its influence on transplant assessment processes, optimisation actions triggered by assessment findings, healthcare utilisation, and longer-term clinical and patient-reported outcomes. Outcomes are collected longitudinally over a two-year follow-up period to characterise trajectories before and after transplant listing and, where applicable, transplantation.

The study also incorporates a preliminary health economic evaluation to explore the feasibility of estimating costs and outcomes associated with KT-CGA. Pseudonymised data are securely shared with King's College London to support exploratory analyses of healthcare utilisation and quality-adjusted life years, informing the design of a future definitive economic evaluation.

Findings from this feasibility trial will inform the refinement of the KT-CGA intervention, outcome selection, and trial procedures, and will be used to support the design of a future multicentre randomised controlled trial evaluating the effectiveness and cost-effectiveness of KT-CGA in older kidney transplant candidates.

• Days Alive and Out of Hospital at 180 days (DAOH-180) [Срок оценки: 180 days from index date (date of KT-CGA for intervention group; equivalent index clinic date for control group)]
• Kidney transplant waitlisting status [Срок оценки: 6 months, 12 months, and 24 months after index study visit]
• Kidney transplantation status [Срок оценки: 12 months and 24 months after index study visit]
• Length of hospital stay associated with kidney transplantation [Срок оценки: From transplant admission through hospital discharge (hospital stay, up to 30 days post-transplant)]
• Number of investigations requested [Срок оценки: Up to 24 months after index study visit]
• Kidney graft survival [Срок оценки: 12 months and 24 months after transplantation]
• Overall survival [Срок оценки: 12 months and 24 months after index study visit]
• Days Alive and Out of Hospital at 365 days (DAOH-365) [Срок оценки: 365 days after index study visit]
• Days Alive and Out of Hospital at 730 days (DAOH-730) [Срок оценки: 730 days after index study visit]
• New diagnoses or clinical findings following KT-CGA [Срок оценки: Up to 6 months after KT-CGA]
• Medication changes prompted by KT-CGA [Срок оценки: Up to 6 months after KT-CGA]
• Therapy referrals initiated following KT-CGA [Срок оценки: Up to 6 months after KT-CGA]