Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that allows for the destruction of a tumor under radiological imaging guidance.

This procedure, less invasive than conventional surgery, allows for a faster recovery and return home. This procedure requires significant precision to ensure the most complete destruction of the tumor, while also preserving organs near the lesion. During general anesthesia, respiratory movements complicate radiological localization and tumor destruction.

The principle of High-Frequency Jet Ventilation (HFJV) involves using a device that ventilates a small volume of air and oxygen at a specific pressure, called driving pressure, at a high frequency.

This ventilation mode reduces respiratory movements while ensuring continuous ventilation and oxygenation. This respiratory stability allows for the precision necessary to superimpose images for tumor localization and destruction.

There are no recommendations regarding the driving pressure setting for HFJV for tumor thermal ablation. The method tested in this research is based on patient's height to optimize the driving pressure when using HFV.

The main objective of this research is to evaluate the impact of driving pressure settings, on respiratory function, taking into account patient's height.

On the day of the procedure, the driving pressure setting for the HFJV will be randomly assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height).

The research will be conducted using medical data collected during patient care. Patient participation will last for the duration of their hospital stay, approximately two days.

• Efficiency of the personalized setting compared to a fixed setting of 1.4 bars [Срок оценки: Immediately after the procedure]
• Efficiency of the personalized setting compared to a fixed setting of 1.9 bars [Срок оценки: Immediately after the procedure]
• Efficiency of the personalized setting compared to a fixed setting of 2.4 bars [Срок оценки: Immediately after the procedure]
• Efficiency for each of the four events comprising the composite criterion of the customized setting compared to all three other groups [Срок оценки: Immediately after the procedure]
• Efficiency for each of the four events comprising the composite criterion, of the customized setting compared to a fixed setting of 1.4 bars [Срок оценки: Immediately after the procedure]
• Efficiency for each of the four events comprising the composite criterion, of the customized setting compared to a fixed setting of 1.9 bars [Срок оценки: Immediately after the procedure]
• Efficiency for each of the four events comprising the composite criterion, of the customized setting compared to a fixed setting of 2.4 bars [Срок оценки: Immediately after the procedure]
• Risk factors for respiratory complications [Срок оценки: Immediately after the procedure]
• Oxygen saturation [Срок оценки: Immediately after the procedure]
• Nu-Desc score [Срок оценки: At day 0]
• Patient's surgical pathway [Срок оценки: From time of randomization until the time of care unit discharge assessed up to one day]
• Patient journey during the stay [Срок оценки: From time of randomization until the time of hospital discharge assessed up to one day]