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Набор скоро начнётся NCT07395453

Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder

— Наблюдательное Obsessive - Compulsive Disorder Obsessive Compulsive Disorder (OCD) Obsessive Compulsive Behavior Substance Abuse Disorder

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD), Obsessive Compulsive Behavior, Substance Abuse Disorder. Базовые параметры: 18 лет — 50 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
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Официальное название

Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder and Its Correlates

Обзор

This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder. Patients aged 18-50 years attending the addiction management inpatient and outpatient services at Assiut University Hospital, and healthy controls recruited from relatives, friends, and hospital staff, will complete structured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale, and other standardized scales for psychiatric symptoms, cognition, and quality of life. The main objective is to estimate the prevalence and severity of obsessive-compulsive symptoms in substance use disorder and examine their associations with sociodemographic and clinical factors, addiction severity, and quality of life in the recovery stage.

Подробное описание

Substance use disorders and obsessive-compulsive disorder are chronic, relapsing conditions that share underlying neurobiological mechanisms related to compulsivity and have substantial impact on functioning and quality of life. Clinical experience and prior research suggest that obsessive-compulsive symptoms may be under-recognized among individuals with substance use disorders, where they can worsen psychiatric comorbidity, complicate treatment, and impair recovery.

The current study will recruit 102 adults aged 18-50 years, including 51 patients with a diagnosed substance use disorder (single or polysubstance) from the inpatient and outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital, and 51 control participants without substance use disorder drawn from relatives, friends, and hospital workers. All participants must be in a non-intoxicated, non-withdrawal state and able to provide informed consent; individuals with severe psychiatric disorders (such as schizophrenia, bipolar disorder, major depressive disorder with severe features, or anorexia nervosa), severe medical illness, or marked cognitive impairment will be excluded.

Data collection will include a structured sociodemographic and clinical sheet, brief psychiatric interview, and administration of validated instruments such as the Yale-Brown Obsessive-Compulsive Scale, Obsessive Compulsive Drug Use Scale, Symptom Checklist-90-R, Montreal Cognitive Assessment, and Hamilton scales for anxiety and depression, along with urine analysis for substances. The primary objective is to assess the correlation between obsessive-compulsive symptoms in patients with substance use disorder and both symptom severity and quality of life, while secondary objectives address compulsive aspects of addiction, craving in patients with obsessive-compulsive symptoms, and potential implications for management strategies.

Первичные конечные точки

  • Severity of Obsessive-Compulsive Symptoms in Patients with Substance Use Disorder Measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Total Score [Срок оценки: Baseline (study enrollment during recovery stage defined as non-intoxication and non-withdrawal); single assessment]

Критерии участия

Критерии включения

--Adults aged 18-50 years.

  • Willing and able to provide informed consent and participate in the study assessments.
  • For the case group: patients with a diagnosed substance use disorder (single or polysubstance) attending the inpatient or outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital.
  • For the control group: relatives, friends, or hospital workers without substance use disorder, recruited through invitation or advertisement.

Критерии исключения

  • Severe psychiatric comorbidities such as schizophrenia, major depressive disorder, bipolar disorder, or anorexia nervosa.
  • Current intoxication or acute withdrawal state from substances.
  • Severe medical conditions including end-stage renal disease, metastatic cancer, severe heart failure, or chronic obstructive pulmonary disease.
  • Severe cognitive impairment

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Случай-контроль

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07395453 · OCD in substances use disorder

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗