Molecular Indicators of Systematic Fitness
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: There is no intervention..
- Кому может быть актуально
- Состояния в реестре: Healthy Adult, Fitness Testing, Athlete, Aging. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- США
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are: 1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak? 2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles? 3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)? 4. What is the analytic reliability of the predictor biomarkers?
Подробное описание
Prospective observational cohort with baseline cross-sectional assessment; optional longitudinal follow-up with repeat VO₂max and blood collection in a subset. No intervention is assigned by the investigators. The investigators are amassing a large dataset of diverse individuals with directly measured VO2max paired with blood samples to support robust biomarker development.
Вмешательства
- Другое There is no intervention.
The investigators are not administering an intervention for this study. To opportunistically capture prospective data, the investigators give participants the option for re-testing after a period of time where participants are undergoing a self-directed intervention (i.e., no influence of the research staff), such as training for a marathon or other fitness event.
Первичные конечные точки
- A multi-analyte biomarker panel to predict maximal aerobic capacity [Срок оценки: Day 1]
- The change in VO2max/VO2peak and a multi-analyte biomarker panel after a self-directed training program. [Срок оценки: From day 1 through study completion, average of 3 months]
Критерии участия
Критерии включения
- Be ≥18 years old
- Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
- Be willing to complete VO₂max testing, blood draw, and questionnaires.
- Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)
Критерии исключения
- Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
- Contraindications or unwillingness to undergo venipuncture
- Acute illness (fever, significant respiratory illness) at the time of testing
- Failure to comply with procedures.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
США · 1 центр
- VO Health, Inc. — New Haven
Идентификаторы
NCT: NCT07393841 · 9554ed94-872a-4b5c-8a42-13e51f