Early Oral Carbohydrate Solution vs Clear Liquid Diet in Acute Pancreatitis
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Oral Carbohydrate Solution, Clear Liquid diet.
- Кому может быть актуально
- Состояния в реестре: Acute Pancreatitis. Базовые параметры: 18 лет — 70 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Пакистан
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Comparison of Oral Carbohydrate Solution Versus Clear Liquid Diet in Acute Pancreatitis:A Randomized Controlled Trial
Обзор
Background: Acute pancreatitis (AP) is an inflammatory condition associated with increased metabolic demands and negative nitrogen balance, making early nutritional support a critical component of management. Concentional practice favored prolonged fasting and delayed oral intake; however, recent evidence supports early oral feeding. Oral carbohydrate solutions (OCS) may provide early caloric support with minimal pancreatic stimulation, but data comparing OCS with clear liquid (CL) diets which is current practice remain limited, particularly in South Asian populations.The Convential diet (CD )group started at liquid diet then progressed towards soft and then solid diet experienced recurring pain at a considerably higher rate than the oral high carbohydrate solution (OCS )group providing essential calories,(13.2% vs. 3.8%, p \< 0.001).OCS showed decrease rate of post prandial recurrent abdominal pain. Objective: To compare oral carbohydrate solution versus clear liquid diet as the initial oral feeding strategy in patients with acute pancreatitis, focusing on feeding intolerance and length of hospital stay. Methods: This prospective randomized controlled trial will be conducted at a tertiary-care hospital in Lahore, Pakistan. Adult patients (18-70 years) with mild to moderately severe acute pancreatitis will be randomized to receive either an oral carbohydrate solution (10% dextrose in water) or a clear liquid diet as the initial oral feed. The primary outcomes will be feeding intolerance within 24 hours and length of hospital stay. Secondary outcomes include time to successful oral feeding, time to soft diet, changes in pain scores, inflammatory markers (CRP, WBC), glycemic response, need for nutritional escalation, complications, and patient satisfaction. Data will be analyzed using SPSS version 26, with a p-value ≤ 0.05 considered statistically significant. Conclusion: If proven safe and effective, oral carbohydrate solution may serve as a simple, cost-effective and well-tolerated alternative to clear liquid diets for early oral feeding in acute pancreatitis, particularly in resource limited settings.
Вмешательства
- Пищевая добавка Oral Carbohydrate Solution
Participant will be allocated in oral carbohydrate solution group.Participant will receive an oral carbohydrate solution initiated after clinical stabilization.It will be be administrated orally with volume and frequency standardized for all participants and advancement according to study protocol. - Пищевая добавка Clear Liquid diet
Participant will receive a standard clear liquid diet initiated after clinical stabilization as per routine institutional practice in measured frequncy and volume and advancement according to study protocol.
Первичные конечные точки
- rate of feeding intolerance [Срок оценки: Upto 24 hours after initiating first oral feed]
- Length of hospital Stay [Срок оценки: From hospital admission to discharge in days]
Критерии участия
Критерии включения
- Age range between 18 years and 70 years
- Diagnosis of mild or moderately severe acute pancreatitis
- Hemodynamically stable
- Able to tolerate oral intake
- Provided written informed consent
Критерии исключения
- Severe acute pancreatitis
- Chronic pancreatitis
- Pregnancy
- Uncontrolled diabetes mellitus
- Known malabsorption syndrome,
- Patients requiring immediate enteral tube feeding or parenteral nutrition,
- Known allergy or intolerance to carbohydrate solutions,
- Persistent retching or vomiting
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Рандомизированное
- Модель
- Параллельные группы
- Маскирование
- Открытое
- Основная цель
- Поддерживающая терапия
Центры проведения
Пакистан · 1 центр
- Jinnah Hospital Lahore — Lahore
Идентификаторы
NCT: NCT07375186 · ERB198/07/01-0-1-2026/AIMC/JHL