Short-term Effects of Broccoli-derived Glucoraphanin on Recovery From Eccentric Muscle Damage

Официальное название

SHORT-TERM EFFECTS OF BROCCOLI-DERIVED GLUCORAPHANIN ON RECOVERY FROM ECCENTRIC MUSCLE DAMAGE: A DOUBLE-BLIND RANDOMIZED CROSSOVER STUDY

Обзор

Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains unknown. This study aims to evaluate whether short-term supplementation with broccoli-derived glucoraphanin will improve recovery from exercise-induced muscle damage. In a randomized, double-blind, placebo-controlled crossover design, fifteen participants will consume either high-glucoraphanin broccoli powder (320 μg) or placebo for one week, followed by elbow flexor eccentric exercise and continued supplementation. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology will be measured at baseline, immediately post-exercise, and at 48 and 96 hours post-exercise.

Вмешательства

• Пищевая добавка broccoli powder consumption
  Participants underwent two separate sessions of muscle-damaging exercise targeting the elbow flexors: (1) following seven days of broccoli powder consumption (condition X), and (2) following an equivalent placebo regimen (condition Y). The broccoli supplementation consisted of 10 g of broccoli powder \[a freeze-dried glucoraphanin-rich broccoli powder (99.5% broccoli and 0.5% mustard seed)\] dissolved in 125 mL of boiling water, providing 320 μg of glucoraphanin per serving. It was consumed when
• Пищевая добавка Placebo (no broccoli-derived bioactives)
  The placebo powder, matched in appearance and preparation, contained no broccoli-derived bioactives.

Первичные конечные точки

• Peak torque, Nm/s [Срок оценки: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.]
• Range of motion, degree [Срок оценки: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.]
• Arm girth, mm [Срок оценки: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.]

Вторичные конечные точки (2)

• Soreness, points [Срок оценки: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.]
• Creatine kinase, IU/L [Срок оценки: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.]

Критерии участия

Критерии включения

• no resistance training experience in the past 6 months, no arm injuries in the past 2 years, no illnesses in the month prior to data collection, and no known allergies to broccoli or other cruciferous vegetables.

Критерии исключения

• incomplete participation.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07373106 · MNLKIN(M)-2024-574

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗