Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging

Официальное название

Role of Macrophage/Monocyte Mediated Inflammatory Response in Diminished Anesthetic Requirements During Aging

Обзор

The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are: * Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery? * How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers? * Is there an association between age, levels of circulating inflammatory cytokines, and monocyte/macrophage phenotypes with anesthetic requirements? If there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage/monocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population. Participants will: * Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements. * Undergo electroencephalographic (EEG) monitoring during the anesthetic period. * Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes. * Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations. * Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.

Первичные конечные точки

• Frontal EEG alpha-band power [Срок оценки: Perioperative]

Вторичные конечные точки (6)

• Time-to-loss of consciousness [Срок оценки: Perioperative]
• Intraoperative anesthetic requirements [Срок оценки: Perioperative]
• Time to emergence [Срок оценки: Perioperative]
• Cytokine circulating profile [Срок оценки: Baseline]
• Monocyte/Macrophage phenotype in blood and peritoneal samples [Срок оценки: Periprocedural]
• Blood-brain barrier permeability [Срок оценки: Baseline]

Критерии участия

Критерии включения

• Age between 18-30 years or over 60 years old
• Scheduled for abdominal surgery
• General anesthesia planned with or without spinal anesthesia
• Able and willing to provide written informed consent.

Критерии исключения

• Chemotherapy or systemic corticosteroid use within the past 2 weeks.
• Pregnancy.
• Active sepsis or systemic infection.
• Emergency surgery.
• Requirement of ketamine or dexmedetomidine during the first hour of anesthesia.
• History or diagnosis of: stroke with persistent neurological deficit, dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, central nervous system autoimmune disorders, systemic autoimmune diseases, or infectious diseases of the central nervous system.
• Current treatment with immunomodulatory medications.
• Psychiatric disorders with psychotic features.
• Use of psychoactive or psychotropic recreational drugs within the week prior to surgery.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Чили · 1 центр

• Hospital Clínico Universidad de Chile — Santiago

Идентификаторы

NCT: NCT07372417 · OAIC N°1538/25

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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