Administration of Fiber as a Dietary Supplement to Improve the Management of Alcohol Withdrawal

Our study proposes testing a new therapeutic target for alcohol addiction: the gut microbiota, which could have a major impact on the prognosis for these patients, or for other addictive behaviors. Dietary fiber can modify alcohol-related intestinal dysbiosis and improve alcohol-induced changes in the intestinal barrier. Given the potential life-threatening nature of alcohol dependence, our study is the first to evaluate the effectiveness of a high-fiber diet in reducing alcohol consumption, increasing alcohol abstinence rates, and improving addictive behavior, cravings, and anxiety and depression symptoms in patients with severe alcohol addiction. The secondary objectives will allow us to study certain mechanisms involved in these effects, with a particular focus on the gut-brain axis. Given the difficulty of managing this chronic condition, if our results are positive, dietary fiber and dietary modulation could become an additional therapeutic option for alcohol withdrawal, improving prognosis and directly benefiting these patients. Furthermore, compared to other treatments used for alcohol addiction, fiber, through its mode of action, could also improve alcohol-related complications.

Although there is no official maximum intake for dietary fiber, excessive consumption, especially when the amount is increased dramatically over a short period of time, can cause minor, non-severe side effects such as gas and bloating. However, our intervention will not exceed the maximum recommended fiber intake recommended by scientific societies, which will reduce the risk of adverse effects. The constraints for patients are minimal and mainly involve eating the bite-sized pieces in addition to their usual meals and completing specific questionnaires to determine their impact on diet, addictive behaviors, and quality of life.

Subjects participating in the study will receive fiber-enriched food bite-sized pieces (16 bite-sized pieces/day for a total of 16 g of fiber: 8 g of inulin and 8 g of pectin) developed by Carembouche every day for 28 days. To increase compliance, different flavors will be offered (citrus, coffee, vanilla, chocolate) for the patient to choose from at the time of inclusion. The bite-sized pieces will be packaged in batches, one package per day, to be stored at room temperature. The bite-sized pieces will be supplied by Carembouche and stored in the department in a closed cupboard, away from light and in accordance with the manufacturer's instructions. Patients will receive the bite-sized pieces during their hospital stay and will return home with the quantity needed for the following 7 days. During the visit on day 14, patients will receive the quantity needed for the remaining 14 days of the protocol. The treatment includes a phase of gradual dose increase with 4 bite-sized pieces on day 1, 8 on day 2, 12 on day 3, and 16 from day 4 until the end of the study. During this adaptation period, patients will be able to choose flavors according to their taste preferences.

• Markers of intestinal integrity (intestinal permeability and bacterial translocation) assessed by plasma measurements of lipopolysaccharide (LPS). [Срок оценки: From day 0 to day 28]
• Markers of intestinal integrity (intestinal permeability and bacterial translocation) assessed by plasma measurements of lipopolysaccharide binding protein (LPB) [Срок оценки: From day 0 to day 28]
• Markers of intestinal integrity (intestinal permeability and bacterial translocation) assessed by plasma measurements of flagellin. [Срок оценки: From day 0 to day 28]
• Markers of intestinal integrity (intestinal permeability and bacterial translocation) assessed by plasma measurements of faecal albumin. [Срок оценки: From day 0 to day 28]
• Markers of intestinal integrity (intestinal permeability and bacterial translocation) assessed by plasma measurements of zonulin. [Срок оценки: From day 0 to day 28]
• Markers of macrophage and neutrophil activation assessed by plasma assays of sCD163. [Срок оценки: From day 0 to day 28]
• Markers of macrophage and neutrophil activation assessed by plasma assays of sCD206. [Срок оценки: From day 0 to day 28]
• Markers of macrophage and neutrophil activation assessed by plasma assays of HMGB1. [Срок оценки: From day 0 to day 28]
• Markers of macrophage and neutrophil activation assessed by plasma assays of osteopontin. [Срок оценки: From day 0 to day 28]
• Evolution of the microbiome profile using 16s DNA sequencing [Срок оценки: From day 0 to day 28]
• Plasma levels of pro-inflammatory cytokines [Срок оценки: From day 0 to day 28]
• Changes in biological and behavioural markers of alcohol consumption measured by plasma levels of carbohydrate-deficient transferrin (CDT) [Срок оценки: From day 0 to day 28]