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Идёт набор NCT07369739

Golidocitinib Combined With Selinexor for CAEBVD

Фаза II / Фаза III С лечением Lymphohistiocytosis EBV CAEBV

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: golidocitinib, Selinexor (combination therapy).
Кому может быть актуально
Состояния в реестре: Lymphohistiocytosis, EBV, CAEBV. Базовые параметры: 18 лет — 70 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Golidocitinib Combined With Selinexor for the Treatment of Chronic Active Epstein-Barr Virus Disease (CAEBVD): A Multicenter, Prospective, Single-arm Clinical Study

Обзор

This study is a multicenter, prospective, single-arm clinical investigation, with patients with CAEBVD as the main research subjects, to evaluate the effectiveness of the combined treatment regimen of golidocitinib and selinexor.

Вмешательства

  • Препарат golidocitinib
    golidocitinib 150 mg once daily.
  • Препарат Selinexor (combination therapy)
    selinexor 40 mg once weekly.

Первичные конечные точки

  • Disease Activity [Срок оценки: Weeks 8 after the start of treatment]
  • EBV-DNA [Срок оценки: Weeks 8 after the start of treatment]

Критерии участия

Критерии включения

  • CAEBVD diagnosed in accordance with the Consensus on the Diagnosis and Treatment of Chronic Active Epstein-Barr Virus Disease (2025 Edition).
  • Aged ≥ 18 years and ≤ 70 years, regardless of gender.
  • Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
  • Before the initiation of the study, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal (ULN); total bilirubin ≤ 2 × ULN; serum creatinine ≤ 1.5 × ULN.
  • Routine blood test: absolute neutrophil count ≥ 1 × 10#/L; platelet count ≥ 50 × 10#/L; hemoglobin ≥ 60 g/L.
  • Coagulation function test requirements: international normalized ratio (INR) ≤ 2.0; prothrombin time (PT) ≤ 1.5 × ULN.
  • Women of childbearing potential must have a negative pregnancy test result, and be willing to take effective contraceptive measures during the trial period and for ≥ 12 months after the last dose; all male subjects must take contraceptive measures during the trial period and for ≥ 6 months after the last dose.
  • Signed informed consent form.

Критерии исключения

  • Evidence of EBV-associated hematological diseases or malignancies, such as hemophagocytic lymphohistiocytosis, lymphomatoid granulomatosis, post-transplant lymphoproliferative disorder, non-Hodgkin's lymphoma, Burkitt lymphoma, nasopharyngeal carcinoma, and gastric cancer.
  • Having received any of the following treatments: prior treatment with any JAK inhibitor; administration of any investigational drug within 12 weeks prior to the first dose of the study drug; concurrent enrollment in another clinical study.
  • A history of other primary malignancies within 5 years prior to the first dose of the study drug, excluding locally curable malignancies that have received curative treatment (e.g., basal or squamous cell carcinoma of the skin, superficial bladder cancer, or carcinoma in situ of the prostate, cervix, or breast).
  • A history of organ transplantation (e.g., liver transplantation, kidney transplantation).
  • Planned hematopoietic stem cell transplantation during the study period.
  • Active hepatitis B (defined as positive hepatitis B surface antigen \[HBsAg\] at screening, or a peripheral blood hepatitis B virus DNA titer > 1×10³ copies/mL); active hepatitis C (defined as positive anti-hepatitis C virus antibody \[HCV-Ab\] and HCV-RNA at screening); positive serum HIV antigen or antibody; a history of syphilis.
  • Having undergone major surgery within 4 weeks prior to the first dose, or anticipating the need for major surgery during the study period.
  • Pregnant or lactating women.
  • A history of severe mental illness or drug abuse.
  • Uncontrolled infections (including pulmonary infection, intestinal infection); active major visceral hemorrhage (including gastrointestinal bleeding, alveolar hemorrhage, intracranial hemorrhage).
  • Hypersensitivity to the components of the study drug, or a history of severe allergic diathesis.
  • Patients who are unable to comply with the requirements during the trial and/or follow-up phase.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Не применимо
Модель
Одна группа
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Китай · 1 центр
  • Beijing Friendship Hospital — Пекин

Идентификаторы

NCT: NCT07369739 · GS for CAEBVD

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗