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Набор скоро начнётся NCT07369518

Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae

— Наблюдательное ISOLATION OF KLEB. by Culture on macConkey Agar Antibiotic Sensitivity Testing of Different Antibiotics According to Clsi 25 Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae Detection of Resistance Gene in Isolates Using Conventional Pcr

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Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: . - Genotypic detection of carbapenemase genes by conventional PCR..
Кому может быть актуально
Состояния в реестре: ISOLATION OF KLEB. by Culture on macConkey Agar, Antibiotic Sensitivity Testing of Different Antibiotics According to Clsi 25, Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae, Detection of Resistance Gene in Isolates Using Conventional Pcr. Базовые параметры: Без ограничений · Все.
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Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Египет
Следующий шаг
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Официальное название

Effect of Ceftazidime-Avibactam Against Carbapenemase-Positive Klebsiella Pneumoniae Causing Health Care-Associated Infections

Обзор

Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups. Bacterial identification by Gram stain, culture and biochemical rections * analysisThe resistance pattern of the isolates will be detected by disc diffusion method. * phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes (KPC, VIM, IMP, OXA-48, NDM) by conventional PCR.

Подробное описание

Carbapenem-resistant Enterobacterales (CRE) poses an urgent global public health threat, with more than 1,100 documented deaths, as reported in a 2019 antibiotic resistance publication by the U.S. Centers for Disease Control and Prevention.

Carbapenem-resistant Enterobacterales, including carbapenem-resistant Klebsiella pneumoniae (CRKP), is associated with higher mortality compared with infections caused by carbapenem-susceptible Enterobacterales infections Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups.

Bacterial identification by Gram stain, culture and biochemical rections

* analysisThe resistance pattern of the isolates will be detected by disc diffusion method. * phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes (KPC, VIM, IMP, OXA-48, NDM) by conventional PCR.

Вмешательства

  • Генная терапия . - Genotypic detection of carbapenemase genes by conventional PCR.
    Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups. Bacterial identification by Gram stain, culture and biochemical rections - analysisThe resistance pattern of the isolates will be detected by disc diffusion method. - phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes

Первичные конечные точки

  • 1 ISOLATION OF KLEB. by culture on macConkey agar [Срок оценки: 6 months from January to may]
  • Antibiotic sensitivity testing of different antibiotics according to clsi 25 [Срок оценки: 6 months from January to may]
  • Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae [Срок оценки: 6 months from January to may]
  • Detection of resistance gene in isolates using conventional pcr [Срок оценки: 6 months from June to December]
  • Detection of some virulence genes using conventional pcr [Срок оценки: 6 months from June to December]

Критерии участия

Inclusion Criteria: Infections caused by klebsiella pneumoniae like skin infections, chest infections, surgical site infections, and urinary tract Infections.-

Критерии исключения

  • Infections caused by any organisms other than klebsiella pneumoniae and carbapenem resistant klebsiella pneumoniae by mechanism other than carbapenemases production.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Случай-контроль

Центры проведения

Египет · 1 центр
  • Faculty of medicine Sohag University — Sohag

Идентификаторы

NCT: NCT07369518 · Soh-Med-25-12-2MS

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗