Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries

Официальное название

Clinical Efficacy and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride to Arrest Incipient Carious Lesions in Permanent Molar Teeth With or Without Application of LED Light: A Randomized Clinical Trial

Обзор

The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light application on caries arrest of initial enamel pits and fissure caries for permanent teeth of young adults

Вмешательства

• Другое International Sliver Diamine Fluoride
  It is the gold standard; it is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
• Другое Local brand Egyptian Silver Diamine Fluoride
  It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
• Другое Silver Fluoride
  It is a water-based remineralizing agent with an application time of 60 seconds.
• Другое International Sliver Diamine Fluoride with LED light
  It is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.
• Другое Local brand Egyptian Silver Diamine Fluoride with LED light
  It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED application for 20 seconds.
• Другое Silver Fluoride with LED light
  It is a water-based remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.

Первичные конечные точки

• Caries arrest [Срок оценки: After 3, 6, and 12 months.]

Критерии участия

Критерии включения

• high caries risk dental students
• Males or females
• Medically free
• Not taking medication
• At least had one active carious tooth
• Posterior permanent teeth
• ICDAS 2

Критерии исключения

• non-Egyptian students
• Lack of compliance
• Allergic reaction to the materials used
• Pregnancy
• Dental students cannot give consent
• Teeth that will be extracted for orthodontic reasons
• Dental fluorosis
• Hypo calcified teeth
• Systemic diseases affecting teeth, such as amelogenesis imperfecta
• Severe periodontal affection

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Профилактика

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07366645 · 3344515

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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