Effect of Cardamom and Peppermint Oils on Chemotherapy-Related Nausea-Vomiting and Food Intake

Официальное название

Effect of Cardamom and Peppermint Oils on Chemotherapy-Related Nausea-Vomiting and Food Intake: Randomized Controlled Study

Обзор

The aim of this study is to evaluate the effect of inhaled cardamom oil on chemotherapy-related nausea, vomiting, and food intake and to compare these effects with those of inhaled peppermint oil.

Подробное описание

Chemotherapy is an effective treatment method used to control cancer systemically by destroying cancer cells or controlling their growth. This treatment inhibits nucleic acid synthesis, thereby preventing DNA and RNA synthesis, and has both cytotoxic and anticancer properties. However, chemotherapy also affects rapidly dividing cells, leading to undesirable side effects. Among these, nausea and vomiting are common and quality-of-life-reducing side effects that affect approximately 80% of patients undergoing chemotherapy.

The pathophysiology of nausea and vomiting is based on mechanisms such as the stimulation of the vomiting center and the chemoreceptor trigger zone, as well as the stimulation of enterochromaffin cells and vagal afferent neurons. Failure to manage these symptoms can lead to serious problems such as malnutrition, dehydration, anorexia, and fluid-electrolyte imbalance. Therefore, antiemetic drugs and various integrative methods (acupuncture, acupressure, behavioral interventions, music therapy, relaxation exercises, hypnotherapy, and aromatherapy) are used to manage nausea and vomiting.

Aromatherapy with various essential oils such as peppermint, ginger, rose, cardamom, lavender, and chamomile has been found to be effective in preventing nausea and vomiting. The effect of peppermint oil on chemotherapy-related nausea and vomiting is well-documented; however, research on cardamom oil is limited. There are few studies in the literature evaluating the effect of cardamom oil on these symptoms. The aim of this study is to evaluate the effect of inhaled cardamom oil on chemotherapy-related nausea, vomiting, and food intake and to compare these effects with those of inhaled peppermint oil.

Вмешательства

• Другое Peppermint Oil
  Thirty minutes before the chemotherapy session begins, one drop of essential oil will be applied to a piece of gauze. The gauze will then be attached to the patient's collar with a safety pin, positioned 20 cm away from the patient's nose. This procedure will be performed three times a day for five consecutive days.
• Другое cardomom oil
  Thirty minutes before the chemotherapy session begins, one drop of essential oil will be applied to a piece of gauze. The gauze will then be attached to the patient's collar with a safety pin, positioned 20 cm away from the patient's nose. This procedure will be performed three times a day for five consecutive days.
• Другое sweet almond oil
  Thirty minutes before the chemotherapy session begins, one drop of essential oil will be applied to a piece of gauze. The gauze will then be attached to the patient's collar with a safety pin, positioned 20 cm away from the patient's nose. This procedure will be performed three times a day for five consecutive days.

Первичные конечные точки

• Chemotherapy-Related Nausea-Vomiting and Retching [Срок оценки: five consecutive days.]
• Food Intake [Срок оценки: five consecutive days.]
• Chemotherapy-Related Nausea [Срок оценки: five consecutive days.]
• Food Frequency Form [Срок оценки: five consecutive days.]
• Anthropometric Measurements1 [Срок оценки: Measurements will be taken twice, on the first and fifth days.]
• Anthropometric Measurements2 [Срок оценки: Measurements will be taken twice, on the first and fifth days.]
• Anthropometric Measurements3 [Срок оценки: Measurements will be taken twice, on the first and fifth days.]

Критерии участия

Критерии включения

• Volunteered to participate in the study,
• Received at least one cycle and are continuing to receive either Adriamycin-cyclophosphamide or Adriamycin-cyclophosphamide-fluorouracil chemotherapy protocols,
• Have an intact sense of smell.

Критерии исключения

• Under 18 years of age,
• Have neurocognitive impairment and are unable to answer the questionnaire,
• Have a condition that may trigger nausea and vomiting, such as vertigo or motion sickness,
• Have a chronic respiratory disease (with a history of asthma or other reactive airway diseases),
• Have a known history of allergies,
• Have a history of prolonged or excessive alcohol use,
• Use any scented products during the intervention period,
• Receive other complementary therapies for nausea and vomiting.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Поддерживающая терапия

Центры проведения

Turkey (Türkiye) · 1 центр

• Eskişehir City Hospital — Eskişehir

Идентификаторы

NCT: NCT07318779 · Chemotherapy

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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