Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

After consenting and completing the baseline measures, participants will be assigned (like flipping a coin) to the immediate treatment group or the control group. The immediate treatment group will participate in the intervention for six weeks while the control group waits. At the end of six weeks, both groups will complete the measures again, and then the control group will have a chance to participate in the intervention. See table below for the timeline of the study for each group.

Study Stage Immediate Intervention Group Waitlist Control Group

1. Baseline Measures - Complete online demographic, mood, and symptom questionnaires

* May skip any questions * Study team emails to confirm participation Same as Immediate Group 2. Randomization (like flipping a coin) Receive email stating you were assigned to the Immediate Group and will begin the program right away Receive email stating you were assigned to the Waitlist Group and will begin the program after 6 weeks Weeks 1-6 Attend six weekly 1-hour group sessions (in person on the campus of the University of Pennsylvania in room 450 of the NBS building located at 425 S. University Avenue or via Zoom) Waiting period (no sessions yet) End of Week 6 Complete symptom measures again and provide feedback on the program Complete symptom measures at the end of the waiting period Weeks 7-12 No additional sessions during this time Attend six weekly 1-hour group sessions (in person in NBS 450 or via Zoom) End of Week 12 - Complete symptom measures again and provide feedback on the program Final Follow-Up (3 months after completing the program) Complete the symptom questionnaires one last time Complete the symptom questionnaires one last time

Intervention: The intervention is a stress management and mindfulness-based program developed and led by Dr. Melissa Hunt, who is a licensed clinical psychologist with expertise in chronic health conditions and mindfulness interventions. She will be assisted by four research coordinators who are undergraduate psychology majors at the University of Pennsylvania. Participants will also have access to an app called Blackfulness. It is a mindfulness meditation app designed specifically for black people. The in person sessions will take place in person at The Neural and Behavioral Sciences (NBS) Building (425 S University Ave, Philadelphia, PA 19104) Room 450. Remote sessions will take place virtually via Zoom video conferencing. People who elect the in person sessions may choose to attend some sessions remotely if weather or health necessitates it.

Week Focus Goals

1 Stress, Health, and Pain Education • Learn how psychological stress affects health and SCD pain crises

* Learn deep diaphragmatic breathing and basic relaxation skills to lower stress and improve pain management 2 Cognitive Therapy Skills • Learn CBT techniques to rethink situations, reduce stress, and respond less reactively * Practice identifying unhelpful thoughts and replacing them with more balanced ones 3 Self-Care \& Barriers to Change • Explore self-care strategies (sleep, exercise, wellness habits) * Discuss barriers to self-care and ambivalence about change * Learn ways to build more wellness activities into daily life. 4 Navigating the ER \& Medical Encounters • Learn effective ways to communicate with doctors and nurses unfamiliar with SCD * Review suggested scripts and role-play interactions with medical personnel * Practice advocacy skills to make sure your voice is heard 5 Mindfulness Meditation I • Introduction to mindfulness practices that decrease emotional and physical reactivity * Build self-compassion skills * Optional use of the Blackfulness app for between-session practice (requires agreeing to the app's privacy policies) 6 Mindfulness Meditation II \& Mindful Movement • Continue mindfulness practice, including gentle mindful movement and stretching * Learn ways to integrate mindfulness into daily routines

• Beck Depression Inventory [Срок оценки: Baseline, 6 weeks and 3 month follow-up]