Delirium and Heart Failure

Официальное название

Accuracy of Different Biomarkers for Predicting Delirium in Older Adults With Heart Failure

Обзор

Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology. This study aims to compare the predictive value of SII and the TyG ratio among other chemical and physiological biomarkers for diagnosing delirium and detecting its severity in older adults with heart failure. These biomarkers reflect different pathophysiological pathways implicated in delirium, including inflammation, cardiovascular stress, and metabolic dysfunction. By evaluating their individual and combined predictive abilities, this research seeks to identify potential tools for early identification of patients at high risk for delirium

Вмешательства

• Другое Comprehensive Geriatric Assessment
  multidimensional assessment of cognition, physical, function, mood, social status of the participants
• Другое the Confusion Assessment Method (CAM test) or CAM-ICU
  standardized tool designed to quickly and accurately diagnose delirium by assessing four key features: acute mental change, inattention, and either disorganized thinking or altered consciousness. The original CAM is used for communicative patients on general wards, relying on conversation, while the CAM-ICU is adapted for critically ill, often non-verbal patients in the ICU, using non-verbal tasks and sedation scales. By providing a rapid, reliable method for identifying this often-missed condit
• Другое Delirium Rating Scale - Revised-98
  The Delirium Rating Scale-Revised-98 (DRS-R-98) is a standardized, expert-rated clinical tool designed specifically to measure the severity of delirium and help distinguish it from other psychiatric disorders, such as dementia, depression, and schizophrenia. Unlike the CAM/CAM-ICU, which provides a simple "yes/no" diagnosis, the DRS-R-98 quantifies how severe a patient's delirium is at a given point in time and tracks changes in that severity over the course of the illness
• Диагностический тест blood biomarkers
  complete blood count(to obtain systemic inflammatory index) ,triglyceride (TG) and glucose, Liver and kidney function tests and serum electrolytes level

Первичные конечные точки

• the sensitivity and specificity of different biomarkers of delirium in heart failure older patient [Срок оценки: Within 24 hours of hospital admission]

Вторичные конечные точки (2)

• in hospital morbidity [Срок оценки: From enrollment to the hospital discharge about 6 weeks]
• In hospital mortality [Срок оценки: From enrollment to hospital discharge about 6 weeks]

Критерии участия

Критерии включения

Heart failure stage C

Критерии исключения

• cognitive impairment
• Major Neurological Conditions: (e.g., stroke, traumatic brain injury).
• Hematological diseases that affect platelet, neutrophil, and lymphocyte counts.
• Cardiogenic Shock
• Sepsis
• Ongoing Treatment with Immunosuppressants, or corticosteroids

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Египет · 1 центр

• Ain Shams University hospitals — Cairo

Идентификаторы

NCT: NCT07302737 · FMASU MD195/2025

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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