Набор скоро начнётся NCT07299877

Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block

Фаза IV С лечением Brachial Plexus Blocks

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Group A (Dexamethasone), Group B (Dexmedetomidine), Group C (Dexamethasone + Dexmedetomidine).
Кому может быть актуально: Состояния в реестре: Brachial Plexus Blocks. Базовые параметры: 20 лет — 65 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Египет
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Официальное название

Perineural Dexamethasone, Dexmedetomidine or Their Combination: an Effort to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block: A Triple-Blind Randomized Controlled Trial

Обзор

Dexmedetomidine, an α2 adrenoceptor agonist, and dexamethasone, a potent anti-inflammatory steroid, are commonly used, effective, and safe adjuvants to peripheral nerve block (PNB). Both have been found to delay and reduce the incidence of rebound pain (RP), prolong the duration of sensory and motor block, and enhance analgesia without causing significant respiratory depression. Few studies have explored the effectiveness of dexmedetomidine or dexamethasone as sole adjuvants to PNB for preventing or reducing RP. However, no study has directly compared the effectiveness of these two drugs in reducing RP when used as adjuvants to local anesthetic (LA) in PNB. Due to differences in their mechanism of action, their effects on RP may differ significantly. The investigators hypothesized that the combination of dexamethasone and dexmedetomidine reduces the incidence of RP when used as adjuvants to LA in PNB.

Вмешательства

Препарат Group A (Dexamethasone)
8 mg of dexamethasone will be added to the local anesthetic. The local anesthetic used in all cases was a mixture of 10 ml of 2% xylocaine and 10 ml of 0.5% bupivacaine.
Препарат Group B (Dexmedetomidine)
1 microgram/kg of dexmedetomidine will be added to the local anesthetic. The local anesthetic used in all cases was a mixture of 10 ml of 2% xylocaine and 10 ml of 0.5% bupivacaine.
Препарат Group C (Dexamethasone + Dexmedetomidine)
8 mg of dexamethasone + 1 microgram/kg dexmedetomidine will be added to the local anesthetic. The local anesthetic used in all cases was a mixture of 10 ml of 2% xylocaine and 10 ml of 0.5% bupivacaine.

Первичные конечные точки

The incidence of rebound pain after the end of anesthesia [Срок оценки: 24 hours]

Вторичные конечные точки (8)

Onset of Rebound Pain [Срок оценки: 24 hours]
Duration of Rebound Pain [Срок оценки: 24 hours]
Severity of Rebound Pain [Срок оценки: 24 hours]
Time to first analgesic request [Срок оценки: 24 hours]
Incidence of sleep disturbances due to surgical site pain [Срок оценки: 48 hours]
Pain score [Срок оценки: 24 hours]
Consumption of fentanyl [Срок оценки: 48 hours]
Patient satisfaction. [Срок оценки: 24 hours]

Критерии участия

Критерии включения

from 20-65 years old
and ASA physical status I or II and III,
and of either gender,
who provided informed, written, and valid consent,
were scheduled for elective orthopedic upper limb surgeries for traumatic fractures under Supraclavicular Brachial Plexus Block.