Набор скоро начнётся NCT07299721

Brain Ultrafast Ultrasound Imaging

— Наблюдательное CHD - Congenital Heart Disease

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Ultrafast ultrasound (UFUS).
Кому может быть актуально: Состояния в реестре: CHD - Congenital Heart Disease. Базовые параметры: 0 лет — 2 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Brain Ultrafast Ultrasound Imaging: Application in Pediatric Cardiology: Brain Ultrafast

Обзор

Congenital heart defects affect 1 in 100 births in France, with rising prevalence due to better care. Despite improved survival, 40% of children post-surgery face neurological impairments, and some of them show brain lesions. Causes include heart defects, genetic syndromes, and surgeries. Some heart defects and support systems increase cerebral risks. Monitoring cerebral perfusion is difficult to assess but emerging ultrafast ultrasound offers real-time, non-invasive blood flow insights.

Подробное описание

Congenital heart defects affect 1 in 100 live births in France. While incidence remains stable, prevalence is rising due to improved medical care, with cases expected to double by 2050. Despite increased survival, neurological comorbidities remain a major concern, with 40% of patients undergoing childhood cardiac surgery experiencing impairments and 73% presenting MRI-detectable brain lesions postoperatively. These injuries result from congenital heart defects, haemodynamic disturbances, genetic syndromes, and neonatal surgeries with extracorporeal circulation.

Some heart defects, such as systemic-to-pulmonary shunts and cyanotic heart diseases, impair cerebral perfusion, increasing the risk of hypoxia and stroke. Mechanical circulatory support systems (e.g. ECMO, cardiopulmonary bypass) also contribute to cerebral risks due to hypoperfusion and clotting complications.

Cerebral autoregulation helps maintain stable perfusion despite blood pressure variations. However, bedside cerebral perfusion monitoring remains challenging leading to reliance on indirect methods like near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD), both with limitations. Ultrafast ultrasound (UFUS) is an emerging non-invasive technique that enables real-time quantification of cerebral blood flow, offering new insights into neonatal cerebral haemodynamics.

Вмешательства

Другое Ultrafast ultrasound (UFUS)
Ultrafast ultrasound imaging(UFUS), ultrasound images at a very high rate, using a Verasonics system (ultrasound open platform).

Первичные конечные точки

Cerebral blood volume variation [Срок оценки: at baseline]
Cerebral blood volume variation [Срок оценки: at baseline]

Вторичные конечные точки (12)

Evolution of Arterial blood pressure [Срок оценки: at baseline]
Evolution of central venous blood pressure [Срок оценки: at baseline]
Evolution of left atrial pressure [Срок оценки: at baseline]
Evolution of SpO2 [Срок оценки: at baseline]
Evolution of SaO2 [Срок оценки: at baseline]
Evolution of SvO2 [Срок оценки: at baseline]
Evolution of PaCO2 [Срок оценки: at baseline]
Evolution of PaO2 [Срок оценки: at baseline]
Evolution of Hemoglobinemia [Срок оценки: at baseline]
Inotropic drugs dosages [Срок оценки: at baseline]
Vasopressive drugs dosages [Срок оценки: at baseline]
Sedation dosages [Срок оценки: at baseline]

Критерии участия

Критерии включения

Every patient under 2 years old any sex or gender hospitalised in the congenital heart disease unit of the intensive care and anaesthesia for cardiovascular surgery, CHU de Bordeaux.
Open anterior fontanella
congenital heart disease
cardiac shock necessitating mechanical circulatory support.
Social security affiliation
Parental or legal guardian's non-opposition