Набор скоро начнётся NCT07292454

Prevalence of Helicobacter Pylori on Patients With Chronic Inflammatory Bowel Disease (IBD) at the CHU of Guadeloupe

— Наблюдательное HELICOBACTER PYLORI INFECTIONS Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Biopsies.
Кому может быть актуально: Состояния в реестре: HELICOBACTER PYLORI INFECTIONS, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis). Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Guadeloupe
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Clinical and experimental data suggest that dysbiosis may play a pivotal role in the pathogenesis of intestinal bowel disease (IBD). However, to the best of our knowledge, the composition of gastric and of intestinal microbiome has never been investigated in a population with IBD according to the presence/absence of Helicobacter pylori (H. pylori) in the stomach.

Подробное описание

H. pylori infection is one of the most widely spread infectious diseases in humans. Although the pathogenesis of IBD is unknown, this pathology could result from complex interactions between environmental factors and the intestinal microbiota, with dysbiosis likely being a key factor. In theory, H. pylori infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements. However, various studies indicate that the prevalence of H. pylori infection is low in patients with IBD, suggesting a protective role for this infection in the development of IBD.

The objective of the study is to investigate the potential link between H. pylori infection and IBD. Another objective is to analyze the complex interactions between the gastric and intestinal microbiome in a population with IBD according to the presence or absence of H. pylori in the stomach.

The study will be based on a prospective cohort of patients with IBD receiving medical care at the CHU of Guadeloupe.

Вмешательства

Другое Biopsies
Gastric biopsies are taken during digestive endoscopy as part of routine clinical care. Two additional biopsies (one fundic and one antral) are planned for research purposes, specifically for metagenomic analysis of the gastric microbiome.

Первичные конечные точки

Prevalence of H. pylori infection in patients with Inflammatory Bowel Disease (IBD) [Срок оценки: At the time of endoscopic evaluation (baseline only).]

Вторичные конечные точки (6)

Demographic characteristics according to H. pylori infection status [Срок оценки: Baseline.]
Clinical characteristics according to H. pylori infection status [Срок оценки: Baseline.]
Biological inflammatory markers according to H. pylori infection status [Срок оценки: Baseline.]
IBD-related treatments according to H. pylori infection status [Срок оценки: Baseline.]
Prevalence of gastric intestinal metaplasia and dysplasia according to H. pylori infection status [Срок оценки: Baseline.]
Composition of the gastric microbiome according to H. pylori infection status [Срок оценки: Baseline.]

Критерии участия

Критерии включения

Patients over 18 years old Patients with IBD from the CHU of Guadeloupe Patients benefiting from an investigation of H. pylori infection through gastric biopsies and/or serology at the time of diagnosis of IBD Patients affiliated to the French social security system Free informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research)