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Идёт набор NCT07287280

Comparing CCI and POSSUM for Predicting Oncogynecologic Surgery Complications

Наблюдательное Gynecologic Surgical Procedures Risk Assessment Perioperative Care

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: CCI score, POSSUM score.
Кому может быть актуально
Состояния в реестре: Gynecologic Surgical Procedures, Risk Assessment, Perioperative Care. Базовые параметры: от 18 лет · Женщины.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Таиланд
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Официальное название

A Comparison of the Charlson Comorbidity Index (CCI) vs POSSUM Score for Prediction of Perioperative Complications in Patients Undergoing Oncogynecologic Surgery

Обзор

With the global rates of gynecologic cancers on the rise, optimizing perioperative care is imperative. Accurate risk prediction is essential for enhancing patient care, directing preoperative interventions, and facilitating informed decision-making in oncology. This research compares two widely-used risk assessment tools: the Charlson Comorbidity Index (CCI) and the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), in predicting perioperative outcomes. The CCI predominantly addresses comorbidities, providing simplicity and broad applicability, while POSSUM incorporates both physiological and operative factors for a more comprehensive risk assessment. Despite their application across various surgical specialties, the specific utility of these tools in onco-gynecologic surgery remains insufficiently explored. The study aims to evaluate the effectiveness of CCI and POSSUM in predicting perioperative complications, with a focus on the incidence of these complications, length of hospital stay, and 30-day mortality. The implementation of these risk tools may enhance multidisciplinary risk management, thus improving patient outcomes in gynecologic oncology surgery.

Подробное описание

Onco-gynecologic surgeries, including procedures for ovarian, cervical, uterine, and vulvar cancers, are complex and challenging due to both the technical intricacies of the surgeries and the often compromised health of cancer patients. These procedures carry significant perioperative risks, making optimization of perioperative care critical, especially as global cases of gynecological cancers rise, with millions affected annually. Accurate risk prediction is vital to improve patient outcomes, allowing surgeons and anesthesiologists to tailor preoperative interventions and intraoperative management. These strategies help in identifying high-risk patients, implementing enhanced monitoring, specific anesthetic techniques, or staged surgical approaches to mitigate potential complications.

Two prominent risk assessment tools used in surgical practice are the Charlson Comorbidity Index (CCI) and the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM). The CCI, is a weighted index that considers the number and severity of comorbid conditions to predict mortality risk. Its simplicity and reliance on readily available clinical information have led to its widespread adoption in clinical and research settings. Studies have validated its predictive value across various surgical populations, including oncology patients, although its specific utility in onco-gynecologic surgeries needs further exploration.

In contrast, the POSSUM score offers a more comprehensive risk assessment by incorporating both physiological and operative factors. It includes preoperative variables like age and cardiac signs and considers operative factors like procedural complexity and blood loss. This dual approach provides a nuanced prediction of perioperative risk, useful across diverse surgical fields. Despite POSSUM's broad application, its effectiveness specifically in onco-gynecologic surgeries requires additional investigation to fully ascertain its predictive accuracy and utility.

Currently, our center conducts preoperative evaluations involving anesthesiologists and gynecologists, yet formal risk assessments using CCI or POSSUM have not been implemented. Incorporating these tools could enhance multidisciplinary risk management, involving anesthetic teams, ward nurses, gynecologic oncologists, and intensivists. By systematically evaluating patient history, these indices can promote effective interdisciplinary communication, significantly improve patient safety, and optimize surgical outcomes.

This study aims to compare CCI and POSSUM in predicting perioperative complications, including both anesthetic and surgical complications in onco-gynecologic surgery. Additionally, it seeks to report the incidence of complications, length of hospital stay, and 30-day mortality, providing valuable insights into optimizing patient care in this challenging field.

Вмешательства

  • Другое CCI score
    Charlson comorbidity index included age and medical conditions
  • Другое POSSUM score
    POSSUM included physical status and laboratory investigation

Первичные конечные точки

  • Comparison of CCI and POSSUM to predict perioperative complications [Срок оценки: from the date of starting surgery to the date of hospital discharge, up to 30 days]
Вторичные конечные точки (11)
  • Intraoperative hypotension [Срок оценки: Within 24 hours from starting of surgery]
  • Quantity of intraoperative blood loss [Срок оценки: Within 24 hours from starting of surgery]
  • Rate of blood transfusion [Срок оценки: Within 24 hours from starting of surgery]
  • Rate of vasopressor usage [Срок оценки: from the time staring of surgery to the time of finishing surgery, up to 12 hours]
  • Clavian-Dindo classification of surgical complications [Срок оценки: from the date of starting surgery to the date of hospital discharge, up to 30 days]
  • ICU admission [Срок оценки: within 24 hours postoperative]
  • Reoperation [Срок оценки: within 24 hours postoperative]
  • Myocardial infarction or myocardial injury [Срок оценки: from the date of starting surgery to the date of hospital discharge, up to 30 days]
  • Acute kidney injury [Срок оценки: from the date of starting surgery to the date of hospital discharge, up to 30 days]
  • Postoperative pulmonary complications [Срок оценки: from surgery from the date of starting surgery to the date of hospital discharge, up to 30 days]
  • Mortality rate [Срок оценки: From the day of surgery to 30 days post operation]

Критерии участия

Критерии включения

  • Age > 18 years
  • Patient underwent elective onco-gynecologic surgery

Критерии исключения

  • Patient required emergency surgery from any indication
  • Patient chart that not contained primary outcome data eg. absent of the anesthetic record

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Только случаи

Центры проведения

Таиланд · 1 центр
  • Faculty of Medicine Siriraj Hospital, Mahidol University — Bangkok

Идентификаторы

NCT: NCT07287280 · 339/2568(IRB4) · Si 428/2025

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗