Меню
Набор скоро начнётся NCT07282769

Semaglutide (Wegovy) Treatment for Trichotillomania

Фаза II С лечением Trichotillomania (Hair-Pulling Disorder) Trichotillomania Hair Pulling Disorder Hair Pulling

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Semaglutide.
Кому может быть актуально
Состояния в реестре: Trichotillomania (Hair-Pulling Disorder), Trichotillomania, Hair Pulling Disorder, Hair Pulling. Базовые параметры: 18 лет — 75 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Официальное название

Once Weekly Semaglutide Treatment of Trichotillomania: An Open-Label Study

Обзор

This research study is testing the effectiveness and safety of semaglutide (Wegovy) in people with trichotillomania, also known as hair-pulling disorder.

Подробное описание

The goal of the proposed study is to evaluate the efficacy and safety of semaglutide in individuals with trichotillomania. The hypothesis to be tested is that semaglutide will reduce urges to pull hair and pulling behavior and will be well tolerated in participants with trichotillomania. The proposed study will provide needed pilot data on the treatment of a disabling disorder that currently lacks available options for pharmacological treatment.

The investigators will conduct an open-label pharmacotherapy trial in 10 individuals with trichotillomania. Participants with trichotillomania will be started and continued on medication during an 8-week treatment phase. The study will be the first to use a once weekly Glucagon-like peptide 1 (GLP-1) receptor agonist pharmacological intervention to target urges in trichotillomania and thereby has the potential to set a new standard of care for a range of compulsive behaviors.

Вмешательства

  • Препарат Semaglutide
    All participants in the study will receive semaglutide (Wegovy).

Первичные конечные точки

  • NIMH Trichotillomania Severity Scale [Срок оценки: From screening to 1 week after last dose of study drug]
Вторичные конечные точки (2)
  • Clinical Global Impression-Improvement and Severity Scales [Срок оценки: From screening to 1 week after last dose of study drug]
  • Massachusetts General Hospital Hair Pulling Scale [Срок оценки: From screening to 1 week after last dose of study drug]

Критерии участия

Критерии включения

  • Men and women age 18-75;
  • Diagnosis of current trichotillomania based on DSM-5 criteria and confirmed using the clinician-administered MIDI (13);
  • Hair pulling daily with urges to pull as the trigger in >50% of the episodes of pulling;
  • Women of childbearing age are required to have a negative result on a beta-human chorionic gonadotropin pregnancy test;
  • Women of childbearing potential utilizing a medically accepted form of contraception defined as double barrier, oral contraceptive, injectable contraceptive, implantable contraceptive devices, and abstinence

Критерии исключения

  • Infrequent pulling (i.e. less than daily) or automatic pulling (i.e. no urges to pull);
  • Unstable medical illness or clinically significant abnormalities on laboratory tests, EKG, or physical examination at screen as determined by the investigator;
  • History of seizures;
  • Myocardial infarction within 6 months;
  • Current pregnancy or lactation, or inadequate contraception in women of childbearing potential;
  • A need for medication other than semaglutide with possible psychotropic effects or unfavorable interactions as determined by the investigator;
  • Clinically significant suicidality (defined by the Columbia Suicide-Severity Rating Scale);
  • Lifetime history of bipolar disorder type I or II, schizophrenia, or any psychotic disorder;
  • Current skin picking disorder;
  • Initiation of psychotherapy or behavior therapy within 3 months prior to study baseline;
  • Initiation of psychotropic medications within 3 months prior to study baseline (stable doses will be allowed);
  • Previous treatment with semaglutide;
  • Use of any weight loss medications;
  • Body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) less than 23;
  • Past-year substance use disorder other than tobacco use disorder or mild cannabis use disorder;
  • Recent (30-day) use of illicit drugs except cannabis;
  • History of diabetes, and current medical or neurological illness precluding participation based on physician judgment;
  • Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2A or 2B;
  • History of pancreatitis.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Не применимо
Модель
Одна группа
Маскирование
Открытое
Основная цель
Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07282769 · IRB25-1571

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗