Clinical Study of Acupoint Application on Relieving qi Deficiency and Constipation in Patients Undergoing Chemotherapy

Официальное название

Clinical Study on Acupoint Application Based on the Theory of "State-target Syndrome Differentiation" in Relieving qi Deficiency and Constipation in Patients With Colorectal Cancer Undergoing Postoperative Chemotherapy

Обзор

4.1 Research Content 1. Clarifying the acupoint application scheme for deficiency and constipation in CRC patients undergoing chemotherapy: the preliminary acupoint application scheme for deficiency and constipation in CRC patients was formulated according to the systematic literature search, analysis of acupoint and traditional Chinese medicine prescription, analysis of meridian tropism of acupoints, Chinese herbal medicine taste and meridian tropism, etc., and multidisciplinary expert consultation. Through two rounds of Delphi expert letter consultation, the acupoint application scheme for deficiency and secret of CRC patients undergoing chemotherapy was determined. 2. Randomized controlled trials were conducted to compare the effect of acupoint application scheme and conventional treatment in improving constipation symptoms, total clinical efficacy, and improving patient comfort rate in CRC patients undergoing chemotherapy. 4.2 Key problems to be solved Based on the theory of "state-target dialectics", the analysis of acupoints and traditional Chinese medicine prescriptions, the analysis of meridian tropism of acupoints, the flavor and meridian tropism of Chinese herbs are used to select Chinese herbs that moisten the intestine and relieve defecation, strengthen the central and qi, and explore the acupoint application to provide a basis for more effective application of acupoint application in the treatment of qi deficiency and constipation in patients with CRC chemotherapy, form a generalized integrated Chinese and western medicine diagnosis and treatment plan, and promote the development of integrated Chinese and western medicine. 4.3 Expected Goals 1. Clarify the diagnosis and treatment plan of acupoint application in the treatment of qi deficiency and constipation in patients with colorectal cancer. 2. The flexible application of classic formula and scientific acupoint selection and sticking can effectively relieve qi deficiency and constipation in CRC patients undergoing chemotherapy, improve the total clinical efficacy and comfort of patients. It has been used in clinical practice and promoted to other medical institutions.

Вмешательства

• Препарат Acupoint application
  1. The traditional Chinese medicine patch was prepared according to the ratio of astragalus: tangerine peel: sesame seed seed: white mustard seed = 6:6:2:1, and an appropriate amount of honey was used to make the shape. 2. Timing of application: finger time (6:30 am). 3. Acupoint prescription: Zusanli (bilateral), Zhongwan (CV 12), Qihai (CV 6) and Guanyuan (CV 4). 4. Location of acupoint: the patient went to the supine position or sitting position with knee flexion. Zusanli (Zusanli) is three c
• Поведенческое Routine treatment and nursing of constipation
  1. Diet care: supplement adequate dietary fiber and adequate water intake. 2. Defecation training: regular defecation training in the morning. Patients or their family members should massage the abdomen clockwise for more than 10 minutes every day to increase the amount of activity. 3. Emotional nursing: explain disease-related knowledge, improve patients' understanding of constipation, relieve bad emotions in time, help patients build confidence and actively participate in treatment.

Первичные конечные точки

• The Nimodipine method was used to calculate the total symptom score of patients [Срок оценки: Five days after the intervention]
• Constipation symptom assessment form [Срок оценки: Before and after 5 days of intervention]

Вторичные конечные точки (3)

• Chinese version of Symptom Checklist for Constipation (PAC-SYM) [Срок оценки: Before and after 5 days of intervention]
• Constipation quality of life self-rating scale (PAC-QOL) [Срок оценки: Before the intervention and 5 days after the intervention]
• TCM syndrome rating scale of qi deficiency and constipation [Срок оценки: Before the intervention and 5 days after the intervention]

Критерии участия

Критерии включения

• Clinical diagnosis of colorectal cancer
• Chemotherapy was performed after surgery
• Diagnosis of qi deficiency and constipation
• Age ≥18 years old

Критерии исключения

• Clinical diagnosis of other digestive tract or anal organic diseases
• Observed with severe cardiac, hepatic, renal insufficiency or other complications
• Allergic constitution or allergy to a drug in constipation paste

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Четверное слепое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• The Second Affiliated Hospital of Zhejiang University School of Medicine — Ханчжоу

Идентификаторы

NCT: NCT07276932 · 2025-0322

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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