Role of Omega-6 Fatty Acids in Hepatocellular Carcinoma Development.

Официальное название

Study of Omega-6 Fatty Acids in Patients With Hepatocellular Carcinoma

Обзор

This observational study investigates the association between serum Omega-6 fatty acids and hepatocellular carcinoma development. Adult HCC patients and age - and gender matched healthy controls will be included. Serum Omega-6 levels will be compared between groups to explore potential correlations with disease presence and severity .

Подробное описание

Hepatocellular carcinoma is a leading cause of cancer related deaths worldwide . Omega-6 fatty acids have been suggested to influence liver cancer development .This observational study aims to assess the association between serum Omega-6 fatty acid levels and HCC development .

Adult patients diagnosed with HCC will be recruited from Sohag University Hospital, along with age and gender matched healthy controls . Blood samples will be collected to measure serum Omega-6 levels using standardized bio-chemical assays . clinical and laboratory data , including liver function tests and tumor stage , will also be recorded.

The study will compare Omega-6 levels between HCC patients and controls , and analyze potential correlation with disease severity .Findings may provide insights into the role of Omega-6 fatty acids in HCC pathogenesis and help identify biomarkers for early detection and risk assessment .

Вмешательства

• Пищевая добавка Omega 6 fatty acid
  Participants will receive an oral Omega-6 fatty acid dietary supplement in capsule form. The supplement will be administered once daily with meals for a total duration of 8 weeks. Each capsule contains a standardized dose of omega -6 fatty acids, and participants will be instructed to maintain their usual diet during the study period . compliance will be monitored though follow up visits and capsule count . no additional supplements containing omega fatty acids will be allowed during the interve

Первичные конечные точки

• Serum Omega-6 Fatty Acid Levels [Срок оценки: At baseline]

Критерии участия

Критерии включения

• 1\. Adults aged 18 years and above. 2. Patients with hepatocellular carcinoma (confirmed clinically, laboratory, radiologically, or histopathologically).

3\. Ability and willingness to provide informed written consent. 4. For healthy controls: individuals without liver disease or history of malignancy, matched by age and gender.

5\. For cirrhotic controls: patients with liver cirrhosis without evidence of any malignancy, matched by age and gender.

Критерии исключения

• History of chronic inflammatory (except for liver cirrhosis or HCC) or autoimmune diseases.
• Current use of omega-6 or omega-3 fatty acid supplements.
• Presence of other types of cancer.
• Pregnant or lactating women.
• presence of severe comorbid condition.

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Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07265076 · 06-HCC-Study-2025-A · Soh-Med--25-10-6MS

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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