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Набор скоро начнётся NCT07248137

Acute Effects of Exercise in Peripheral Arterial Disease Patients

Без фазы С лечением Aerobic Physical Exercise Traditional Strength Exercise Circuit Strength Exercise Control

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Aerobic exercise, Traditional strength exercise, Circuit strength exercise.
Кому может быть актуально
Состояния в реестре: Aerobic Physical Exercise, Traditional Strength Exercise, Circuit Strength Exercise, Control. Базовые параметры: 18 лет — 100 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Acute Effects of Different Physical Exercise Conditions in Patients With Peripheral Arterial Disease

Обзор

Peripheral arterial disease (PAD) affects over 200 million people worldwide and is caused by narrowing of the arteries. Intermittent claudication, characterized by pain when walking, is its main symptom. Despite the proven benefits of exercise, there is no optimal protocol for treatment. To analyze the effects of different exercise conditions on proteomic and physiological markers in patients with PAD and to determine their preferences regarding exercise conditions. A clinical cross-over study with four randomized experimental conditions (aerobic training, traditional strength training, circuit training and control) will be conducted. Patients with grade IIa-IIb PAD according to the Leriche-Le Fontaine scale will be recruited from the Department of Angiology and Vascular Surgery Department of the Hospital Clínico Universitario de Valladolid. In each experimental session, measurements of cardiorespiratory capacity, post-exercise oxygen debt, ankle-brachial index, blood flow, peripheral oxygen saturation, perceived exertion, heart rate variability and blood proteome changes will be performed.

Вмешательства

  • Другое Aerobic exercise
    Intermittent walking will be performed on a treadmill (F2W DUAL, BHFitness®, Spain). There will be 8 sets of 2 minutes in duration at an intensity equivalent to the level at which the patient experienced claudication symptoms. The recovery period between each set will be two minutes. All training sessions will conclude with a cool-down period of 5 minutes of walking at 50-60% of peak heart rate, followed by 3 minutes of joint mobility exercises. Throughout the session, heart rate will be continu
  • Другое Traditional strength exercise
    Two sets will be performed with a moderate-to-high effort level (15-16 repetitions out of 20RM) consisting of 6 multi-joint exercises. The recovery period after each set will be two minutes of passive rest. Each participant will be asked to move the load as quickly as possible during each repetition. All training sessions will conclude with a cool-down period of 5 minutes of walking at 50-60% of peak heart rate, followed by 3 minutes of joint mobility exercises. Throughout the session, heart rat
  • Другое Circuit strength exercise
    Two sets (rounds) will be performed with a moderate-to-high effort level (15-16 repetitions out of 20RM) in a circuit consisting of 6 multi-joint exercises. The recovery time between exercises will be the minimum required to change exercises, and the recovery between sets (rounds) will be two minutes of passive rest. Each participant will be asked to move the load as quickly as possible during each repetition. All training sessions will conclude with a cool-down period of 5 minutes of walking at

Первичные конечные точки

  • Blood Flow [Срок оценки: Week 1 (baseline), Weeks 2-4 (15 minutes post-intervention)]
  • Peripheral oxygen saturation [Срок оценки: Week 1 (baseline), Weeks 2-4 (during each intervention session)]
  • Heart rate variability [Срок оценки: Week 1 (baseline), Weeks 2-4 (during intervention and 24, 48, and 72 hours post-intervention)]
  • Proteomics [Срок оценки: Weeks 2-4 (5 minutes prior to exercise and 5 minutos post-intervention)]
Вторичные конечные точки (3)
  • Post-exercise oxygen debt [Срок оценки: Weeks 2-4 (after every intervention session)]
  • Perceived exertion [Срок оценки: Weeks 2-4 (right after every intervention session and 24, 48, and 72 hours post-intervention)]
  • Satisfaction with the type of training [Срок оценки: Weeks 2-4 (right after every intervention session and 24 and 48 post-intervention)]

Критерии участия

Критерии включения

  • Be 18 years of age or older.
  • Patients diagnosed with peripheral arterial disease at grade IIa or IIb according to the Leriche-Fontaine classification.

Критерии исключения

  • Patients with dementia or cognitive impairment.
  • Patients with recent major surgery (≤12 months) or lower limb amputations.
  • Patients institutionalized in healthcare facilities.
  • Patients dependent on a wheelchair.
  • Patients with any other condition contraindicating participation in an exercise program.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Рандомизированное
Модель
Перекрёстный дизайн
Маскирование
Простое слепое
Основная цель
Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07248137 · PI-DOC009- VESSEL-FIT

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗