Emerging Indications for Hyperbaric Oxygen Treatment

Currently, the Undersea and Hyperbaric Medical Society (UHMS) has identified 15 conditions where HBO2 can be considered an approved treatment. These range from decompression illness, where the combination of increased pressure, relief of hypoxia, and reduced inflammation from HBO2 help combat the impaired circulation and endothelial damage caused by bubbles, to radiation injury, where the pulses of oxygen promote angiogenesis and wound healing. Because of HBO2's effects on hypoxia and inflammation, more medical diagnoses exist that can benefit from HBO2. HBO2 is typically given in long courses (20-40 treatments), however, and most centers see only a limited number of patients. Therefore, gathering outcome data on HBO2 treatment has been limited, and often, only case reports or small case series are available to support its use. In addition, practice patterns differ across centers, and some centers may use HBO2 successfully for an indication that other centers may not consider it for. To gather more data on HBO2 applications, outcome data from multiple centers need to be combined. The goal of the Multicenter Registry for Hyperbaric Oxygen Treatment is to collect and aggregate these data.

In a recent publication from our group, we presented data for 45 emerging indications for hyperbaric oxygen treatment. A unifying theme among many of these indications is that they involve hypoxia and/or inflammation as prime drivers of the pathology.

For many of the indications the use of HBOT is based on the underlying pathophysiology, where the presence of hypoxia and/or inflammation indicates that HBOT might be useful. The outcome data, however, are based on case reports or small case series. This project will collect consistently acquired outcome data for indications where HBOT is being used, but the underlying data supporting its use is limited.

• Urogenital Distress Inventory [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Bowel symptoms questionnaire [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Head and Neck Questionnaire [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Perianal Crohn's Symptom Index Questionnaire [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Hip dysfunction and Osteoarthritis Outcome Score (HOOS) Questionnaire [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Wound Score (Strauss Score) [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Subjective Assessment [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Calciphylaxis Measurement Package [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Frostbite Measurement Package [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Pyoderma Gangrenosum Measurement Package [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]
• Raynaud Syndrome Measurement Package [Срок оценки: Within one week of starting HBO2 treatments and within one week completing HBO2 treatments]