Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

Официальное название

Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry. A Randomized Clinical Trial

Обзор

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020). There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office. Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office. Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio. Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Вмешательства

• Препарат lidocaine + epinephrine 1:100,000
  Administration of lidocaine as a local anesthetic during dental extraction.
• Препарат Articaine 4% with epinephrine 1:100,000
  Administration of articaine as a local anesthetic during dental extraction.

Первичные конечные точки

• Number of tubes [Срок оценки: immediately after the procedure]

Вторичные конечные точки (1)

• Pain during dislocation using the Visual Analog Scale (VAS) for pain with a minimum of 0 meaning no pain, and a maximum of 10 meaning the most severe pain ever experienced in life. [Срок оценки: After the procedure]

Критерии участия

Критерии включения

• Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.
• Patients without systemic diseases (ASA I)
• Patients with controlled systemic disease (ASA II)
• Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)
• Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.
• Patients with the ability to understand the procedure and provide informed consent.

Критерии исключения

• Patients with uncontrolled systemic diseases ASA III and pregnant patients.
• Patients requiring trunk techniques (Gow gates, Spix, Carrea)
• Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)
• Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.
• Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.
• Patients with a history of recent substance abuse.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Лечение

Центры проведения

Чили · 1 центр

• CESFAM Dr. Jorge Sabat — Valdivia

Публикации

• Halabi D, Escobar J, Alvarado C, Martinez N, Munoz C. Chlorhexidine for prevention of alveolar osteitis: a randomised clinical trial. J Appl Oral Sci. 2018;26:e20170245. doi: 10.1590/1678-7757-2017-0245. Epub 2018 May 7. PMID 29742264

Идентификаторы

NCT: NCT07231614 · ArtiVsLido

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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