Individual Differences in Cognitive Control Predict Real-time fMRI Neurofeedback Performance

Обзор

The goal of this study is to investgate whether individual differences of cognitive control capacity could predict neurofeedback performance and the behavioral effects resulting from successful anterior insula regulation via interoceptive strategy.

Подробное описание

The experimental protocol comprises two visits with a 3-7 days interval. The first visit includes: (1) completion of standardized psychological questionnaires, (2) pre-test of the heartbeat counting task (HCT), and (3) four validated cognitive control tasks, including the Go/No-Go task, Stroop task, Task-switching task, N-back task. The main task of the second visit is a fMRI task followed by a post-test of the HCT. The MRI scanning protocol includes anatomical scan, two resting-state scans (pre- and post-training), four runs of fMRI neurofeedback training and a transfer run without feedback. During the regulation block of the training task, participants are asked to upregulate the anterior insula activity followed by a pain empathy rating and strategy efficacy rating. All participants receive real-time neurofeedback from the left anterior insula. Scores of questionnaires including Positive and Negative Affect Schedule, Beck Depression Inventory-Ⅱ, Autism Spectrum Quotient, State-Trait Anxiety Inventory, Interpersonal Reactivity Index, Toronto Alexithymia scale, Bermond-Vorst Alexithymia Questionnaire, Interoceptive Confusion Questionnaire, Multidimensional Assessment of Interoceptive Awareness, Cognitive Flexibility Inventory are also collected before the experiment.

Вмешательства

• Другое Real-time fMRI neurofeedback training
  Real-time neurofeedback information is computed using the Turbo Brain voyager (TBV) 4.0 software (Brain Innovation, Maastricht, The Netherlands). Functional images are collected and processed in real time based on contrasts of regulation vs. rest conditions. The BOLD signal of the target region is then transformed into visual bars and displayed to participants via the projector screen while participants keep using regulation strategy (heartbeat interoception in our study) to upregulate the targe

Первичные конечные точки

• BOLD signal of the anterior insula during neurofeedback training [Срок оценки: 1 hour]
• Behavioral measurements in the cognitive control tasks [Срок оценки: 1 hour]

Вторичные конечные точки (4)

• Pain empathy ratings scores [Срок оценки: 1 hour]
• Strategy efficacy rating scores [Срок оценки: 1 hour]
• Intero-ceptive accuracy [Срок оценки: 15 minutes]
• Confidence rating scores of interoceptive sensitivity [Срок оценки: 15 minutes]

Критерии участия

Критерии включения

• Healthy subjects without any past or present psychiatric or neurological disorders

Критерии исключения

• History of brain injury Medical or mental illness and color blindness or weakness.
• The presence of metal in the body or claustrophobia.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Китай · 1 центр

• University of Electronic Science and Technology of China — Чэнду

Идентификаторы

NCT: NCT07211269 · UESTC-neuSCAN-95

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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