Acquired Dyslexia Modeling and Treatment

Официальное название

Evidence-based Modeling for Acquired Dyslexia Treatments

Обзор

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

Вмешательства

• Поведенческое Phono-Motor Therapy
  Orthographic stimuli (letters) are introduced from the beginning as each phoneme is being trained. This maintains the focus on phonology, while emphasizing its relevance to reading. PMT consists of an initial phase focused on training of individual phonemes and phoneme sequences in spoken language, followed by written language tasks. English phonemes are first trained in isolation, followed by phoneme sequences in words and pseudowords. They are trained multi-modally through emphasis on auditory
• Поведенческое Semantic Feature Analysis
  SFA activates semantic features of the target word to help retrieve the spoken form of the word. To target reading, a modified SFA is used with written words rather than pictures as the primary materials. Pictures are instead included for each word as a semantic feature. Stimuli will consist of 80 highly imageable nouns with a range of word frequencies. During treatment the therapist will present a written noun and ask the participant a series of questions about the features of that noun. For ex

Первичные конечные точки

• Woodcock Reading Mastery Test - III [Срок оценки: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.]
• Test words and pseudowords [Срок оценки: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.]

Вторичные конечные точки (2)

• Western Aphasia Battery - Revised [Срок оценки: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.]
• Comprehensive Aphasia Test - Disability Quotient [Срок оценки: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.]

Критерии участия

Критерии включения

• Fluent in English as a first language pre-stroke by self report.
• Normal or corrected-to-normal vision.
• Normal or aided hearing.
• Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
• Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.

Критерии исключения

• Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
• Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
• History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
• Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Нерандомизированное

Модель

Перекрёстный дизайн

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

США · 3 центра

• Florida State University — Tallahassee
• Johns Hopkins University School of Medicine — Baltimore
• Kessler Foundation — West Orange

Идентификаторы

NCT: NCT07209488 · Pro2025001100 · R56DC022256

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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