Идёт набор NCT07203833

Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock

Без фазы С лечением Vasorin Septic Shock Shock Biomarker

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: blood sample.
Кому может быть актуально: Состояния в реестре: Vasorin, Septic Shock, Shock, Biomarker. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Septic shock is the most severe form of infection. Currently, an early specific biomarker for septic shock is needed. Remember that shock situations are numerous, not only septic (eg hemorrhagic, cardiogenic...), and also accompanied by a severe pro-inflammatory state that it is sometimes difficult to distinguish from a septic state. Procalcitonin (PCT) is the most studied biomarker but still lacks sensitivity (77%) and specificity (79%). The investigators hypothesize that the Vasn could become this potential new biomarker and would allow a better diagnosis and thus the need or not to treat patients with antibiotics. The laboratory studies suggest a link between Vasn and septic shock. The goal of this project is to measure and compare plasma Vasn concentrations in 2 groups of patients = group 1: septic shock versus group 2: non-septic shock. Briefly, shock is defined as low blood pressure requiring vasopressor agents with confirmed infection (group 1) or without suspected infection such as patients admitted in intensive care unit post cardiac surgery with CBP (group 2). The investigators will also assess patient 28-day mortality to identify Vasn as a potential prognostic biomarker.

Вмешательства

Биопрепарат blood sample
blood sample in order to measure the concentrations of circulating Vasn

Первичные конечные точки

Vasn plasma concentration at D0 for each group [Срок оценки: day 0]
Vasn plasma concentration in each group [Срок оценки: day 1]
Vasn plasma concentration in each group [Срок оценки: day 3]
Correlation between Vasn plasma concentration and noradrenaline dose peak in each group [Срок оценки: day 0]
Correlation between Vasn plasma concentration and noradrenaline dose peak in each group [Срок оценки: day 1]
Correlation between Vasn plasma concentration and noradrenaline dose peak in each group [Срок оценки: day 3]
Correlation between Vasn plasma concentration and occurrence of an IRA (KDIGO score) in each group [Срок оценки: day 0]
Correlation between Vasn plasma concentration and occurrence of an IRA (KDIGO score) in each group [Срок оценки: day 1]
Correlation between Vasn plasma concentration and occurrence of an IRA (KDIGO score) in each group [Срок оценки: day 3]
Correlation between Vasn plasma concentration and coagulation marker concentration in each group [Срок оценки: day 0]

Критерии участия

Критерии включения

Adults over 18 years.
Patients admitted for less than 24 hours in intensive care unit of the CHU Amiens Picardie.
Group 1: patients with septic shock defined by sepsis with 2 mmol/l Lactates, requiring vasopressors to maintain mean blood pressure at 65 mmHg (despite adequate vascular filling) in the presence of fever (T°>38.3) with a documented or suspected infection
Group 2: patients with a shock defined by arterial hypotension requiring the use of vasopressors with 2 mmol/l Lactates but without suspected infection and apyrexie (T°<38°). For example: vasoplegia post cardiac surgery with CBP or cardiogenic shock or hemorrhagic shock