Menses&Change in Diabetic Girl
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Follow up of female sexual function.
- Кому может быть актуально
- Состояния в реестре: Adolescent Girls, Diabete Mellitus. Базовые параметры: 10 лет — 20 лет · Женщины.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Список центров уточняется — проверьте первичный протокол.
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Menstrual Cycle Changes in Adolescent Girls With Diabetes
Обзор
To assess menstraul cycle changes in adolescent girls with diabetes and to find out the various risk factors
Подробное описание
Type 1 diabetes mellitus (T1DM) is the result of autoimmunity mediated destruction of pancreatic beta cells, ultimately causing insulin deficiency and, consequently, hyperglycemia .
Typically the diagnosis of T1DM is made in childhood or adolescence,but about 40% of affected individuals are diagnosed in adulthood.
Hyperglycemia-related complications can contribute to impairment of endocrine axes, such as the hypothalamic pituitary gonadal (HPG) axis .
Historically, before the introduction of insulin replacement therapy, prepubertal girls wh developed T1DM rarely showed normal sexual development, exhibiting primary amenorrhea .
Although the introduction of insulin drastically changed the natural history of T1DM, allowing restoration of the HPG physiology, menarche delay remained as a typical sign in girls with T1DM .
In addition, women with T1DM report a higher incidence of menstrual irregularities \>30%
compared with control subjects without diabetes .
Accordingly, signs and symptoms of androgen excess, such as acne and hirsutism, are more frequent in women with T1DM than in their age-matched counterparts
These interconnected abnormalities contribute to the reduced fertility observed in women with T1DM, as characterized by fewer pregnancies and live births and earlier menopause compared with women without diabetes.
Вмешательства
- Другое Follow up of female sexual function
We follow up menstrual changes in diabetic adolescent girls to improve the outcome
Первичные конечные точки
- Number of participants with menstrual irregularities [Срок оценки: 12 months (from enrollment)]
Вторичные конечные точки (1)
- Association of menstrual irregularities with HbA1c and BMI [Срок оценки: 12 months (from enrollment)]
Критерии участия
Критерии включения
- Girls with diabetes diagnosed based on ADA guidelines Who reatched menarche of at least 1year duration \[14\]\]
- Another comparable number of age matched non\_diabetic girls will be included as controls.
3/Female adolescents aged 10-18 years
Критерии исключения
- Girls Known thyroid disease or other endocrine disorders affecting menstruation
- Girls taking medications that may affect menstrual cycles like Use of hormonal therapy (e.g., oral contraceptive pills) within the last 6 months
- Menstraul irregularitis prior to diagnosis of diabetes
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Список центров уточняется — проверьте первичный протокол.
Публикации
- Gu YH, Yokoyama K, Mizuta K, Tsuchioka T, Kudo T, Sasaki H, Nio M, Tang J, Ohkubo T, Matsui A. Stool color card screening for early detection of biliary atresia and long-term native liver survival: a 19-year cohort study in Japan. J Pediatr. 2015 Apr;166(4):897-902.e1. doi: 10.1016/j.jpeds.2014.12.063. Epub 2015 Feb 11. PMID 25681196
- Ghitha N, Vathania N, Wiyono L, Pulungan A. Delayed menarche in children and adolescents with type 1 diabetes mellitus: a systematic review and meta-analysis. Clin Pediatr Endocrinol. 2024;33(3):104-112. doi: 10.1297/cpe.2023-0058. Epub 2024 Apr 19. PMID 38993726
- Whitworth KW, Baird DD, Stene LC, Skjaerven R, Longnecker MP. Fecundability among women with type 1 and type 2 diabetes in the Norwegian Mother and Child Cohort Study. Diabetologia. 2011 Mar;54(3):516-22. doi: 10.1007/s00125-010-2003-6. Epub 2010 Dec 19. PMID 21170514
- Samara-Boustani D, Colmenares A, Elie C, Dabbas M, Beltrand J, Caron V, Ricour C, Jacquin P, Tubiana-Rufi N, Levy-Marchal C, Delcroix C, Martin D, Benadjaoud L, Jacqz Aigrain E, Trivin C, Laborde K, Thibaud E, Robert JJ, Polak M. High prevalence of hirsutism and menstrual disorders in obese adolescent girls and adolescent girls with type 1 diabetes mellitus despite different hormonal profiles. Eur PMID 22127492
- Codner E, Soto N, Merino PM. Contraception, and pregnancy in adolescents with type 1 diabetes: a review. Pediatr Diabetes. 2012 Feb;13(1):108-23. doi: 10.1111/j.1399-5448.2011.00825.x. Epub 2011 Oct 13. PMID 21995767
- Strotmeyer ES, Steenkiste AR, Foley TP Jr, Berga SL, Dorman JS. Menstrual cycle differences between women with type 1 diabetes and women without diabetes. Diabetes Care. 2003 Apr;26(4):1016-21. doi: 10.2337/diacare.26.4.1016. PMID 12663566
- Kjaer K, Hagen C, Sando SH, Eshoj O. Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls. J Clin Endocrinol Metab. 1992 Aug;75(2):524-9. doi: 10.1210/jcem.75.2.1639955. PMID 1639955
- Green A, Hauge M, Holm NV, Rasch LL. Epidemiological studies of diabetes mellitus in Denmark. II. A prevalence study based on insulin prescriptions. Diabetologia. 1981 Apr;20(4):468-70. doi: 10.1007/BF00253409. PMID 7016641
Идентификаторы
NCT: NCT07194291 · Menses&Change in diabetic Girl