Study of Gecacitinib-corticosteroid as First-line Therapy for Grade II-IV Acute Graft Versus Host Disease

Официальное название

A Prospective, Single-Arm, Phase II Clinical Study of Gecacitinib-Corticosteroids as First-Line Treatment for Grade II-IV Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Обзор

This trial employs a single-arm, single-center design, planning to enroll 25 patients diagnosed with grade II-IV aGVHD at one center. Patients meeting all inclusion criteria and no exclusion criteria will be enrolled. After enrollment, all patients will receive Gecacitinib combined with methylprednisolone sodium succinate for at least 28 days. After 28 days of Gecacitinib treatment, patients evaluated by the investigator as achieving Complete Response (CR) or Partial Response (PR) may continue study treatment for up to 24 weeks. If patients experience intolerance, disease progression, or require new systemic therapy, treatment will be adjusted.

Подробное описание

All patients will receive the combined treatment of Gecacitinib and methylprednisolone sodium succinate in addition to the existing treatment regimen (Cyclosporin A 150\~250 μg/L and/or Tacrolimus 5\~12 μg/L) or other adjuvant treatments.

Dosage: Gecacitinib PO 50mg Bid; Methylprednisolone sodium succinate IV 2mg/kg/d.

After completing treatment, the Gecacitinib dose may be gradually reduced until discontinuation, per the investigator's discretion.The researchers adjusted the dosage of glucocorticoids according to the patient's condition: Methylprednisolone sodium succinate was gradually reduced.

If disease progresses (aGVHD grade increases by one level) during Gecacitinib treatment, the investigator should initiate other salvage therapy as clinically needed. If aGVHD efficacy evaluation does not reach Complete Response(CR) or Partial Response(PR) after 28 days of Gecacitinib, the investigator should initiate other systemic therapy as clinically needed.

Вмешательства

• Препарат Gecacitinib-Corticosteroid
  Gecacitinib po. 50mg bid at least 28 days
• Препарат Methylprednisolone sodium succinate
  Methylprednisolone sodium succinate IV 2mg/kg/d.

Первичные конечные точки

• Overall Response Rate (ORR) for aGVHD at Day 28 of treatment [Срок оценки: Day 28]

Критерии участия

Критерии включения

• 1\. Voluntarily sign informed consent form (ICF); age ≥18 years at ICF signing.
• 2\. Recipients who underwent non-myeloablative, myeloablative, or reduced-intensity allo-HSCT using bone marrow or peripheral blood stem cells.
• 3\. Have received systemic corticosteroid therapy for no more than 2 days (48 hours).
• 4\. Documented myeloid and platelet engraftment: Absolute Neutrophil Count (ANC) >0.5 × 10⁹/L for 3 consecutive days, platelet count >20 × 10⁹/L for 7 consecutive days without transfusion support (use of growth factors, transfusion support allowed).
• 5\. Clinical diagnosis of Grade II-IV aGVHD according to the MAGIC (Mount Sinai Acute GVHD International Consortium) criteria.
• 6\. ECOG performance status 0-2.
• 7\. Life expectancy greater than 4 weeks.
• 8\. Able to swallow tablets.
• 9\. Capable of complying with study and follow-up procedures.

Критерии исключения

• 1\. Having undergone ≥2 allo-HSCT procedures.
• 2\. SR-aGVHD occurring after unplanned donor lymphocyte infusion (DLI) used for prophylactic treatment of malignancy relapse. \*Note: Patients receiving planned DLI as part of the transplant procedure, not intended for managing malignancy relapse, may be included.\*
• 3\. Concurrent treatment with other JAK inhibitors.
• 4\. Presence of active bleeding.
• 5\. Diagnosed or suspected chronic GVHD.
• 6\. Presence of uncontrolled active infection. Uncontrolled active infection is defined as: hemodynamic instability due to sepsis, or worsening of symptoms, signs, or radiographic findings due to infection. Persistent fever without symptoms or with stable symptoms is not considered an uncontrolled active infection.
• 7\. Presence of unresolved toxicity or complications due to allo-HSCT (excluding aGVHD).
• 8\. Any significant clinical or laboratory abnormality that may affect safety evaluation, such as:

• Uncontrolled diabetes (fasting blood glucose >13.9 mmol/L);
• Hypertension that cannot be controlled to within SBP <160 mmHg and DBP <100 mmHg with two or more antihypertensive agents;
• Peripheral neuropathy (NCI-CTCAE v5.0 Grade 2 or higher).
• 9\. History of NYHA Class III or IV congestive heart failure, uncontrolled or unstable angina, myocardial infarction, cerebrovascular accident, or pulmonary embolism within 6 months before screening.
• 10\. Arrhythmia requiring treatment at screening, or QTc interval (QTcB) >480 ms.
• 11\. Significant renal impairment at screening (serum creatinine >1.5 × ULN).
• 12\. Pre-transplant diagnosed gastrointestinal ulcers, history of gastric/intestinal resection surgery, or other conditions potentially affecting drug absorption.
• 13\. Surgery within 4 weeks before screening without full recovery.
• 14\. Cholestatic disease or hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) at screening (defined as persistent bilirubin abnormality and progressive organ dysfunction not due to GVHD).
• 15\. Active uncontrolled viral infection at screening, e.g., CMV, EBV, HIV (anti-HIV antibody positive), HBV (HBsAg positive, HBV-DNA positive), HCV (anti-HCV antibody or HCV-RNA positive).
• 16\. History of active tuberculosis within 6 months before screening.
• 17\. Epilepsy or use of psychotropic/sedative drugs at screening.
• 18\. Women planning pregnancy, pregnant, or breastfeeding, or patients unable to use effective contraception throughout the trial; male patients unwilling to use condoms during treatment and for 2 days (approx. 5 half-lives) after the last dose.
• 19\. History of other malignancies within the past 5 years, excluding the malignancy for which transplant was performed.
• 20\. Other severe comorbidities deemed by the investigator to potentially affect patient safety or compliance.
• 21\. Suspected allergy to gecacitinib, drugs of the same class, or any excipients.
• 22\. Participation in other investigational drug or medical device clinical trials within 4 weeks before screening.
• 23\. Any other condition considered by the investigator to preclude participation.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

• Dou L, Zhao Y, Yang J, Deng L, Wang N, Zhang X, Liu Q, Yang Y, Wei Z, Wang F, Jiao Y, Li F, Luan S, Hu L, Gao S, Liu C, Liu X, Yan J, Zhang X, Zhou F, Lu P, Liu D. Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial. Signal Transduct Target Ther. 2024 Oct 23;9(1):288. doi: 10.1038/s41392-024-01987-x. PMID 39438467
• Dou L, Peng B, Li X, Wang L, Jia M, Xu L, Li F, Liu D. Ruxolitinib-corticosteroid as first-line therapy for newly diagnosed high-risk acute graft versus host disease: study protocol for a multicenter, randomized, phase II controlled trial. Trials. 2022 Jun 6;23(1):470. doi: 10.1186/s13063-022-06426-2. PMID 35668528
• Liu J, Lv B, Yin H, Zhu X, Wei H, Ding Y. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteers. Front Pharmacol. 2020 Dec 14;11:604314. doi: 10.3389/fphar.2020.604314. eCollection 2020. PMID 33536914

Идентификаторы

NCT: NCT07185633 · 20250824101854977

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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