Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

Официальное название

A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0516 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Metastatic Prostate Cancer

Обзор

The main purpose of this study is to assess the safety and tolerability of AZD0516 as monotherapy and/or in combination with other anti-cancer agents for treatment of metastatic prostate cancer.

Подробное описание

This is a first-in-human modular, Phase I/IIa, open-label, multi-centre study of AZD0516 in participants with metastatic prostate cancer. The study will consist of individual modules, each evaluating the safety, tolerability, preliminary efficacy, PK, pharmacodynamic, and immunogenicity of AZD0516.

Module 1: Evaluates AZD0516 as monotherapy. It may include 3 parts, Part A- Dose Escalation, Part B- Dose Optimisation, and Part C- Efficacy Expansion.

Module 2: Evaluates AZD0516 in combination with AZD9574. It may include 2 parts, Part A - Dose Escalation and Part B Dose Optimisation.

Вмешательства

• Препарат AZD0516
  AZD0516 will be administered via intravenous infusion.
• Препарат AZD9574
  AZD9574 will be administered orally.

Первичные конечные точки

• Module 1 and 2: Parts A and B: Number of participants with Adverse Events (AEs), Serious Adverse Events (SAEs) and Adverse Event of Special Interests (AESIs) [Срок оценки: From Day 1 up to approximately 3 years]
• Module 1 and 2: Part A: Number of participants with Dose Limiting Toxicities (DLTs) [Срок оценки: From Day 1 up to end of DLT period (approximately 21 days)]
• Module 1: Parts B and C and Module 2: Part B: Percentage of participants with Prostate-Specific Antigen (PSA) 50 response rate [Срок оценки: Up to approximately 2 years]

Вторичные конечные точки (12)

• Module 1 and 2: Part A: Percentage of participants with PSA50 response rate [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Percentage of participants with PSA90 response rate [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Time to PSA 50 response (TTPSA50) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Time to PSA response (TTPSA90) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Duration of PSA response 50 (DoPSA50) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Duration of PSA response 90 (DoPSA90) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Percentage of participants with Durable PSA response rate 50 (DRRPSA50) [Срок оценки: Up approximately 2 years]
• Module 1 and 2: Parts A, B and C: Percentage of participants with Durable PSA response rate 90 (DRRPSA90) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Time to PSA Progression (TTPSA) [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Percentage change from baseline in PSA levels [Срок оценки: Up to approximately 2 years]
• Module 1 and 2: Parts A, B and C: Percentage of participants with Overall Response Rate (ORR) [Срок оценки: Up to approximately 3 years]
• Module 1 and 2: Parts A, B and C: Percentage of participants with Best Overall Response (BOR) [Срок оценки: Up to approximately 3 years]

Критерии участия

Main Inclusion Criteria:

• Histologically or cytologically confirmed diagnosis of metastatic adenocarcinoma of the prostate. Focal high grade neuroendocrine features are permitted.
• Measurable PSA ≥ 1 μg/L (≥ 1 ng/mL).
• Surgically or medically castrated with serum testosterone levels ≤ 50 ng/dL (≤ 1.75 nmol/L) within ≤ 28 days before treatment allocation. Ongoing androgen deprivation therapy (ADT) with a gonadotropin releasing hormone (GnRH) modulator for participants who have not undergone bilateral orchiectomy must be initiated at least 2 weeks prior to consent and must continue throughout the study.
• Eastern cooperative oncology group (ECOG) performance status of 0 or 1.
• Adequate organ and marrow function in the absence of blood transfusion or growth factor support (within 21 days prior to the scheduled first dose of study intervention).
• Provision of baseline archival or newly obtained formalin-fixed paraffin-embedded (FFPE) tumour sample is mandatory.
• Documented current evidence of metastatic prostate cancer
• Life expectancy of at least 12 weeks in the opinion of the investigator
• Documented mCRPC progression at screening as assessed by the investigator with at least one of the following criteria:

• PSA progression defined by a minimum of 3 rising PSA levels with an interval of ≥ 1 week between each determination. The PSA value at the screening visit should be ≥ 1 μg/L (1 ng/mL).
• Radiographic disease progression in soft tissue based on response evaluation criteria in solid tumors (RECIST) v1.1 criteria with or without PSA progression as per prostate cancer working group 3 (PCWG3).
• Radiographic disease progression in bone defined as the appearance of 2 or more new bone lesions on a bone scan as per PCWG3 with or without PSA progression.

Main Exclusion Criteria:

• Cancer related spinal cord compression, or brain metastases unless asymptomatic, treated and stable and not requiring continuous corticosteroids at a dose of > 10 mg prednisone/day or equivalent for at least 4 weeks prior to study enrolment.
• History of leptomeningeal carcinomatosis.
• Unresolved toxicities of Grade ≥ 2 (National Cancer Institute Common Terminology Criteria for Adverse Events v5.0) from prior therapy (excluding vitiligo, alopecia, and endocrine disorders that are controlled with replacement hormone therapy).
• Uncontrolled intercurrent illness within the last 12 months.
• Cardiovascular disorder (History of arrhythmia, uncontrolled hypertension, symptomatic hypotension, history of brain perfusion problems, symptomatic heart failure, prior or current cardiomyopathy, severe valvular heart disease)
• History of malignancy
• History of non-infectious interstitial lung disease (ILD)/pneumonitis
• Active infection exclusions, including tuberculosis and infections with Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or Human Immunodeficiency Virus (HIV).
• Any known predisposition to bleeding
• Clinically severe pulmonary compromise
• Participants with Myelodysplastic syndrome (MDS)/Acute Myeloid Leukemia (AML) or with features suggestive of MDS/AML.
• Previous treatment with a STEAP2 targeting modality, chemotherapeutic agent that inhibits topoisomerase activity or metabolic enzymes.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Последовательный дизайн

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

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Идентификаторы

NCT: NCT07181161 · D9520C00001 · 2024-520026-11-00

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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