Effectiveness of Whole Body Vibration on Health Outcomes in Older Adults With Dynapenic Abdominal Obesity

Официальное название

The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity

Обзор

This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life. While some benefits have been observed in the elderly population, there remains a research gap concerning its effectiveness in older adults with dynapenic abdominal obesity. Therefore, the findings of this study will provide new evidence for health interventions targeting this specific group. This research targets outpatients aged 65 and above who meet the criteria for dynapenic abdominal obesity. It aims to evaluate the effects of WBVT on brain activity, osteoporosis, quality of life, and biological markers. The study period is from February 1, 2025, to January 31, 2027, with a planned sample size of 120 participants, equally divided into an experimental group and a control group (60 participants each).

Подробное описание

The purpose of this study is to investigate the effects of whole body vibration training on older adults with dynapenic abdominal obesity in the following areas:

Brain activity: Changes in serum levels of brain-derived neurotrophic factor (BDNF).

Bone mineral density: Measured using dual-energy X-ray absorptiometry (DXA).

Quality of life: Assessed through questionnaires covering improvements in physical health, mental well-being, and social functioning.

Biomarkers: Changes in levels of total cholesterol, high- and low-density lipoprotein cholesterol, C-reactive protein (CRP), and glycated hemoglobin (HbA1c).

Вмешательства

• Поведенческое whole body vibration training
  whole body vibration training and health education booklet
• Поведенческое control group
  health education booklet

Первичные конечные точки

• blood tests [Срок оценки: 24 weeks]
• dual-energy X-ray absorptiometry(DXA) [Срок оценки: 8 months]
• quality of life questionnaire [Срок оценки: 24 weeks]

Критерии участия

Критерии включения

Outpatients aged 65 years or older

Diagnosed with dynapenic abdominal obesity

Able to understand and follow simple instructions

Able to communicate clearly and express their own will

Willing to sign the informed consent form

Критерии исключения

Inability to communicate in Mandarin or Taiwanese, resulting in inability to participate in research activities

Severe visual or hearing impairment that hinders study participation

Presence of cognitive impairment, musculoskeletal or severe osteoporosis-related conditions

Refusal to sign the informed consent form

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

• Zago M, Capodaglio P, Ferrario C, Tarabini M, Galli M. Whole-body vibration training in obese subjects: A systematic review. PLoS One. 2018 Sep 5;13(9):e0202866. doi: 10.1371/journal.pone.0202866. eCollection 2018. PMID 30183742
• Zhang L, Liu S, Wang W, Sun M, Tian H, Wei L, Wu Y. Dynapenic abdominal obesity and the effect on long-term gait speed and falls in older adults. Clin Nutr. 2022 Jan;41(1):91-96. doi: 10.1016/j.clnu.2021.11.011. Epub 2021 Nov 15. PMID 34864458
• Zhang J, Wang R, Zheng Y, Xu J, Wu Y, Wang X. Effect of Whole-Body Vibration Training on Muscle Activation for Individuals with Knee Osteoarthritis. Biomed Res Int. 2021 Mar 26;2021:6671390. doi: 10.1155/2021/6671390. eCollection 2021. PMID 33855078
• Yao G, Chung CW, Yu CF, Wang JD. Development and verification of validity and reliability of the WHOQOL-BREF Taiwan version. J Formos Med Assoc. 2002 May;101(5):342-51. PMID 12101852
• Wang X, Jiang J, Hu W, Hu Y, Qin LQ, Hao Y, Dong JY. Dynapenic Abdominal Obesity and Risk of Heart Disease among Middle-Aged and Older Adults: A Prospective Cohort Study. J Nutr Health Aging. 2023;27(9):752-758. doi: 10.1007/s12603-023-1975-0. PMID 37754215
• Wolf D, Ayon-Olivas M, Sendtner M. BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia. Biomedicines. 2024 Aug 5;12(8):1761. doi: 10.3390/biomedicines12081761. PMID 39200225
• Wang W, Wang S, Lin W, Li X, Andersen LL, Wang Y. Efficacy of whole body vibration therapy on pain and functional ability in people with non-specific low back pain: a systematic review. BMC Complement Med Ther. 2020 May 27;20(1):158. doi: 10.1186/s12906-020-02948-x. PMID 32460819
• Wu S, Ning HT, Xiao SM, Hu MY, Wu XY, Deng HW, Feng H. Effects of vibration therapy on muscle mass, muscle strength and physical function in older adults with sarcopenia: a systematic review and meta-analysis. Eur Rev Aging Phys Act. 2020 Sep 17;17:14. doi: 10.1186/s11556-020-00247-5. eCollection 2020. PMID 32963629

Идентификаторы

NCT: NCT07180485 · B11401015 · DTCRD113-E-14

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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