Idiopathic Pulmonary Fibrosis Cohort of TCM

This study is based on a previously established registry of interstitial lung disease, with traditional Chinese medicine treatment as the exposure factor. A total of at least 1000 IPF patients will be continuously enrolled and followed up for 2 years; it will further observe the pattern of syndromes, disease characteristics, and their interrelationships during disease development, and evaluate the clinical efficacy of traditional Chinese medicine in treating IPF using indicators such as annual acute exacerbation rate and clinical symptoms. Based on the differences in efficacy indicators, it will identify the advantageous population, clarify the clinical efficacy advantage targets, and provide a basis for precision treatment with traditional Chinese medicine.

• Progression-Free Survival(PFS） [Срок оценки: Evaluate the PFS at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]
• All-cause mortality rate [Срок оценки: Up to week 104.]
• Lung transplantation rate [Срок оценки: Up to week 104.]
• The Traditional Chinese Medicine(TCM) Syndromes [Срок оценки: Evaluate the TCM s]yndromes at baseline and at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]
• Clinical symptoms and Signs [Срок оценки: Evaluate the clinical symptoms and signs up at baseline and at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]
• Forced vital capacity (FVC) [Срок оценки: Evaluate the FVC at baseline and at weeks 26, 52, 78 and 104.]
• FVC as the percentage of the predicted value (FVC%) [Срок оценки: Evaluate the FVC% at baseline and at weeks 26, 52, 78 and 104.]
• Diffusing capacity of the lungs for carbon monoxide (DLCO) [Срок оценки: Evaluate the DLCO at baseline and at weeks 26, 52, 78 and 104.]
• DLCO as the percentage of the predicted value (DLCO%) [Срок оценки: Evaluate the DLCO% at baseline and at weeks 26, 52, 78 and 104.]
• 6 Six Minute Walk Distance(6MWD) [Срок оценки: Evaluate the 6MWD at baseline and at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]
• The 30 - second sit - to - stand test(30s STS) [Срок оценки: Evaluate the 30s STS at baseline and at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]
• A Tool to Assess Quality of life (ATAQ-IPF) total scores [Срок оценки: Evaluate the ATAQ-IPF total scores at baseline and at weeks 13, 26, 39, 52, 65, 78, 91, and 104.]