Effect of Contralateral NMES on Quadriceps Activation After ACL Injury or Surgery

Официальное название

Does NMES Applied to the Contralateral Uninjured Side Facilitate Voluntary Quadriceps Activation Before and After ACL Surgery?

Обзор

A major complication after cruciate ligament injury and surgery is arthrogenic muscle inhibition of the quadriceps, which is characterised by a deficit in voluntary muscle activation in the affected leg. This can hinder rehabilitation processes, lead to impaired knee function, and negatively impact the patients' quality of life. The primary objective of this study is to assess whether voluntary quadriceps activation on the injured side is facilitated by the concomitant application of neuromuscular electrical stimulation (NMES) on the contralateral quadriceps.

Подробное описание

The primary objective of this study is to assess whether injured-side voluntary quadriceps activation before and after ACL surgery is facilitated by the concomitant application of NMES on the contralateral quadriceps (uninjured side), in comparison to a control (CTRL) condition that does not involve any contralateral activity (passive rest) and to a voluntary (VOL) condition that involves a maximal voluntary contraction of the contralateral quadriceps.

Вмешательства

• Устройство Neuromuscular Electrical Stimulation
  Studies in healthy individuals have demonstrated that NMES applied to the quadriceps of one limb induces short-term increases in strength and neural drive in the contralateral homologous muscle. Since these effects have only been observed in healthy individuals, it is essential to investigate whether similar responses occur in ACL patients.

Первичные конечные точки

• EMG activity [Срок оценки: Data will be collected at two time points: after ACL injury (within two weeks prior to surgery) and following ACL reconstruction (within three days post-surgery).]

Критерии участия

Критерии включения

• Patients undergoing ACL surgery with semitendinosus tendon autograft in the Schulthess Clinic
• Unilateral and primary ACL injury (with/without diagnoses of additional meniscus injury)

Критерии исключения

• Previous surgery/ligament rupture in injured or uninjured knee or hip
• Severe pain in the uninjured-side quadriceps or knee joint
• Ongoing pregnancy
• BMI >30 kg/m²
• Neuromuscular disease
• Open wounds or tissue injuries on the anterior aspect of the thigh
• Additional rupture of other knee ligaments (posterior cruciate ligament, medial collateral ligament, lateral collateral ligament)
• Implanted metallic/electronic devices (cardiac pacemakers, defibrillators)
• Patients getting a femoralis block (peripheral nerve block) after surgery will be excluded for the post-surgical appointment
• Insufficient language comprehension

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Другое

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07156734 · 2025-00224

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗