Motor Imagery and Action Observation for Gait Function in MS

Официальное название

Effects of Motor Imagery and Action Observation on Gait Initiation and Spatiotemporal Gait Parameters in Multiple Sclerosis

Обзор

This study will investigate whether mentally simulating walking movements while watching others walk can improve walking performance in individuals with Multiple Sclerosis (MS). Participants will be divided into two groups: one group will watch walking videos and imagine themselves walking, while the other group will watch nature scenes. The study will measure muscle activity and walking patterns to assess the effects. The results may help support the use of mental practice techniques to improve mobility in people with MS.

Подробное описание

This study aims to explore the impact of mental simulation of walking movements on walking performance in individuals with Multiple Sclerosis (MS). The participants will be randomly assigned to two groups: the experimental group will watch walking-related videos and engage in mental imagery exercises, imagining themselves walking, while the control group will watch nature scenes without any walking-related content.

Objectives:

To determine whether mental imagery can enhance walking ability and gait parameters in individuals with MS.

To measure the effect of mental simulation on muscle activity and walking patterns, including stride length, walking speed, and balance.

Study Procedure:

The study will consist of multiple sessions, where participants will first undergo baseline assessments of walking ability. Following this, they will engage in either the walking video and imagery task (experimental group) or the nature video viewing task (control group) for a predetermined period of time. Measurements of muscle activity using electromyography (EMG) and walking patterns will be recorded before and after the intervention.

Potential Impact:

The results from this study may provide insights into the use of mental practice techniques as a non-invasive intervention to improve mobility in individuals with MS, a population often affected by walking difficulties. Mental imagery could serve as an adjunct therapy to traditional physical rehabilitation methods.

Вмешательства

• Поведенческое Action Observation + Motor Imagery
  Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.
• Поведенческое Nature Video
  Participants will watch a video of nature scenes.

Первичные конечные точки

• Change in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Amplitude [Срок оценки: Before and immediately after the intervention]
• Change in Tibialis Anterior and Gastrocnemius Medialis Muscle Activity Onset Latency [Срок оценки: Before and immediately after the intervention.]
• Change in Step Length [Срок оценки: Before and immediately after the intervention]
• Change in Step Time [Срок оценки: Before and immediately after the intervention]
• Change in Step Width [Срок оценки: Before and immediately after the intervention]
• Change in Double Support Period [Срок оценки: Before and immediately after the intervention]
• Change in Gait Velocity [Срок оценки: Before and immediately after the intervention]
• Change in Cadence [Срок оценки: Before and immediately after the intervention]

Вторичные конечные точки (8)

• Motor Imagery Vividness [Срок оценки: Baseline only]
• Mental Chronometry Ratio [Срок оценки: Baseline only]
• Limb Laterality Recognition Performance [Срок оценки: Baseline only]
• Cognitive Status [Срок оценки: Baseline only]
• Fatigue Level [Срок оценки: Baseline only]
• Anxiety and Depression [Срок оценки: Baseline only]
• Disability Level [Срок оценки: Baseline only]
• Visual Acuity [Срок оценки: Baseline only]

Критерии участия

Критерии включения

• A confirmed diagnosis of multiple sclerosis (MS) by a neurologist
• No history of relapse within the past 3 months and not currently experiencing a relapse
• A score of 24 or higher on the standardized Mini Mental State Examination

Критерии исключения

• Presence of serious health conditions affecting the muscles, heart, lungs, or metabolism that could interfere with participation
• History of other neurological disorders, head injury, or chronic psychiatric conditions
• Chronic pain lasting longer than six months
• Significant muscle stiffness in the legs that may affect EMG recordings
• Hearing difficulties
• Vision problems as determined by the Snellen visual acuity test

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Поддерживающая терапия

Центры проведения

Turkey (Türkiye) · 1 центр

• Hacettepe University, Faculty of Physical Therapy and Rehabilitation — Ankara

Публикации

• Wright DJ, Williams J, Holmes PS. Combined action observation and imagery facilitates corticospinal excitability. Front Hum Neurosci. 2014 Nov 27;8:951. doi: 10.3389/fnhum.2014.00951. eCollection 2014. PMID 25505880
• Rocca MA, Meani A, Fumagalli S, Pagani E, Gatti R, Martinelli-Boneschi F, Esposito F, Preziosa P, Cordani C, Comi G, Filippi M. Functional and structural plasticity following action observation training in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1472-1487. doi: 10.1177/1352458518792771. Epub 2018 Aug 7. PMID 30084706
• Gil-Bermejo-Bernardez-Zerpa A, Moral-Munoz JA, Lucena-Anton D, Luque-Moreno C. Effectiveness of Motor Imagery on Motor Recovery in Patients with Multiple Sclerosis: Systematic Review. Int J Environ Res Public Health. 2021 Jan 9;18(2):498. doi: 10.3390/ijerph18020498. PMID 33435410
• Chye S, Valappil AC, Wright DJ, Frank C, Shearer DA, Tyler CJ, Diss CE, Mian OS, Tillin NA, Bruton AM. The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses. Neurosci Biobehav Rev. 2022 Dec;143:104911. doi: 10.1016/j.neubiorev.2022.104911. Epub 2022 Nov 5. PMID 36349570
• Salamci M, Salci Y, Topuz S, Yalcin AI, Acar Ozen P, Tuncer A. Gait initiation in multiple sclerosis patients with and without functional loss. Mult Scler Relat Disord. 2023 Nov;79:104990. doi: 10.1016/j.msard.2023.104990. Epub 2023 Sep 4. PMID 37708821

Идентификаторы

NCT: NCT07137624 · FTREK25/48

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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