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Идёт набор NCT07136532

Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography

— Наблюдательное Septic Shock Echocardiography Guided Fluid Management

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: echocardiography.
Кому может быть актуально
Состояния в реестре: Septic Shock, Echocardiography Guided Fluid Management. Базовые параметры: 1 мес. — 16 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Египет
Следующий шаг
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Обзор

The goal of this study is to evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock. and To evaluate the diagnostic accuracy of Aortic peak velocity and velocity time integral (VTI)variation in patients with septic shock during their fluid resuscitation phase as a reliable predictor of fluid responsiveness.

Подробное описание

The goal of this study is to evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock.

and To evaluate the diagnostic accuracy of Aortic peak velocity and VTI variation in patients with septic shock during their fluid resuscitation phase as a reliable predictor of fluid responsiveness.All patients included in the study will be evaluated clinically and radiologically at fluid resuscitative phase of septic shock after fluid resuscitation.

This evaluation will include:

• Clinical examination:

Clinical evaluation will be done initially and after fluid resuscitation:

* Vital data (systolic, diastolic, and mean blood pressure, heart rate, Temperature). * Urine output, capillary perfusion time, Central venous pressure (CVP). * Detailed physical examination (chest, heart, and abdomen). • Investigations:

A) Laboratory:

* Complete blood count. * Venous blood gases. * C-reactive protein. * Kidney function tests. * Albumin. * Serum lactate. * Fibrinogen * Serum electrolytes. * Fibrinogen to albumin ratio

B) Imaging:

Echocardiography (measurement of stroke volume, stroke volume index, cardiac index, systemic vascular resistance index, Aortic peak velocity and VTI variation,, inferior vena cava (IVC)collapsibility index and IVC distensibility index)

Вмешательства

  • Диагностический тест echocardiography
    Echocardiography will be performed using the ultrasound system echocardiographic equipment (Siemens Advanced Clinical Ultrasound Systems Optimized Navigation (ACUSON) P500), carotid doppler ultrasonography (Carotid blood flow and Corrected flow time) by using the ultrasound system echocardiographic equipment (Siemens ACUSON P500) . Those measurements will be done at time zero and upon completion of fluid resuscitation . • Statistical Analysis: All data will be collected, tabulated, and statist

Первичные конечные точки

  • To evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock. [Срок оценки: one year]

Критерии участия

Критерии включения

  • Children aged 1 month to 16 years.
  • Patients with septic shock admitted at the PICU during their fluid resuscitative phase were included.Septic shock was diagnosed according to phoenix sepsis score 2024
  • Exclusion criteria:
  • Acquired and congenital heart disease.
  • Acquired and congenital renal disease.
  • Vascular anomalies (e.g. arteriovenous malformation, aneurysm).
  • Suspected intracranial hypertension.
  • Skin lesions or bandages at the sites of ultrasound or echo-cardiography examinations.
  • Anatomical anomalies of the neck.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Египет · 1 центр
  • Ain shams university _faculty of medicine — Cairo

Публикации

  • Liteplo AS, Schleifer J, Marill KA, Huang CK, Gouker SK, Ratanski D, Diamond E, Filbin MR, Shokoohi H. Carotid Ultrasound in Assessing Fluid Responsiveness in Patients with Hypotension and Suspected Sepsis. Shock. 2021 Sep 1;56(3):419-424. doi: 10.1097/SHK.0000000000001755. PMID 33577247

Идентификаторы

NCT: NCT07136532 · MD07/2024/2025

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗