Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction

Обзор

This prospective cohort study will enroll 20 patients clinically diagnosed with first-time acute myocardial infarction (AMI) who underwent interventional procedures (including percutaneous coronary intervention \[PCI\] and balloon angioplasty) at the Affiliated Hospital of Qingdao University. Patient data, including routine blood and urine tests, blood biochemistry, electrocardiograms (ECG), imaging studies, and interventional procedure records, will be collected to assess eligibility for enrollment. The study procedures include patient screening and enrollment, obtaining informed consent, baseline assessment (including medical history, laboratory tests, ECG, etc.), an ¹⁸F-Pentixafor PET/MR examination, and follow-up. Images will be blindly assessed by at least two specialized physicians from the Radiology and Nuclear Medicine departments. The study aims to investigate the utility of ¹⁸F-Pentixafor PET/MR in evaluating coronary microcirculatory function, cardiac function, myocardial viability, myocardial inflammatory response, and the efficacy of interventional therapy in AMI patients post-procedure. Additionally, it will perform risk stratification and prognostic analysis for the enrolled patients.

Первичные конечные точки

• The myocardial uptake of 18F-Pentixafor was quantified using SUVmax and SUVmean values derived from PET imaging. [Срок оценки: At baseline (within 1 week of enrollment)]
• Left ventricular ejection fraction (LVEF) assessed by cardiac MRI to evaluate left ventricular function [Срок оценки: At baseline (within 1 week of enrollment)]
• Infarct Characterization [Срок оценки: At baseline (within 1 week of enrollment)]

Вторичные конечные точки (3)

• Myocardial T1 Values and Extracellular Volume (ECV) [Срок оценки: At baseline (within 1 week of enrollment)]
• Myocardial T2 values [Срок оценки: At baseline (within 1 week of enrollment)]
• Myocardial Strain Analysis [Срок оценки: At baseline (within 1 week of enrollment)]

Критерии участия

Критерии включения

• Patients with a clinical diagnosis of first-episode acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI) were included. All patients had complete baseline clinical data, with baseline cardiac magnetic resonance (CMR) examinations performed within 7 days post-PCI and follow-up CMR completed at 6 months post-procedure.

Критерии исключения

• Patients with severe cardiac decompensation (Killip class 4) or clinically unstable conditions.

Patients with coexisting valvular heart disease, congenital heart disease, pulmonary hypertension, cardiomyopathy, or persistent atrial fibrillation that may confound cardiac structural/functional assessments.

Prior history of myocardial infarction, coronary revascularization (PCI/CABG).

Concurrent severe systemic diseases including hematologic disorders, malignancies, rheumatic/autoimmune diseases, or severe hepatic/renal failure.

Contraindications to CMR (claustrophobia, pacemaker implantation, etc.).

Pregnant, breastfeeding, or women of childbearing potential without effective contraception.

Sexually active individuals of reproductive age unwilling to use reliable contraception.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• The Affiliated Hospital of Qingdao University — Qingdao

Идентификаторы

NCT: NCT07130409 · QYFYECR2025-74

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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