Идёт набор NCT07119177

Long-term Evaluation of Gestational Endocrine & Metabolic Dynamics

— Наблюдательное Gestational Diabetes Mellitus (GDM) Non-communicable Chronic Diseases

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально: Состояния в реестре: Gestational Diabetes Mellitus (GDM), Non-communicable Chronic Diseases. Базовые параметры: от 18 лет · Женщины.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Китай
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Long-Term Effects of Gestational Diabetes Mellitus on Postpartum Chronic Non-Communicable Diseases: A Prospective Cohort Study

Обзор

Gestational diabetes mellitus (GDM) is the most common complication and metabolic disorder during pregnancy, with clear risks to both the mother and fetus. In recent years, the long-term chronic diseases and poor prognosis in GDM women after delivery, as well as the risk of obesity and metabolic disorders in their offspring, have become key research topics. However, due to the long duration of GDM's impact on both the mother and offspring and its involvement in multiple disciplines, high-quality cohort studies are scarce. As a result, there is no definitive conclusion regarding the high-risk factors, natural progression, key mediators, timing of interventions, and targets for GDM's long-term effects on mothers and their offspring. This project intends to initiate a prospective follow-up study, establish a specialized cohort for the long-term effects of GDM on both mothers and their offspring, and complete the characterization of the natural course of non-communicable chronic diseases (NCDs) in GDM women and their offspring. The study will also explore high-risk and mediator factors, and develop predictive models. The goal is to provide education, postpartum follow-up, monitoring, and possibly initiate primary prevention for GDM women to reduce the long-term NCD risks, ultimately improving their life expectancy and providing a theoretical basis for intervention. Inclusion Criteria: 1. Adult patients (≥18 years old) who registered for antenatal care and delivered at Peking University Firest Hospital's obstetrics department between 2007 and 2016. 2. Diagnosed with gestational diabetes mellitus (GDM) during pregnancy via an oral glucose tolerance test (OGTT). 3. Signed informed consent. Exclusion Criteria: 1. Lack of pregnancy-related obstetric follow-up records. 2. Inability to cooperate with and complete subsequent scheduled follow-ups.

Первичные конечные точки

Prevalence of type 2 diabetes mellitus [Срок оценки: At 8-17 years postpartum]
Prevalence of metabolic syndrome [Срок оценки: At 8-17 years postpartum]
Prevalence of cardiovascular diseases [Срок оценки: At 8-17 years postpartum]
Prevalence of cognitive function [Срок оценки: At 8-17 years postpartum]
Prevalence of renal disease [Срок оценки: At 8-17 years postpartum]

Вторичные конечные точки (12)

Prevalence of anxiety [Срок оценки: At 8-17 years postpartum]
Thyroid Function [Срок оценки: At 8-17 years postpartum]
Bone Density [Срок оценки: At 8-17 years postpartum]
Offspring Growth and Development [Срок оценки: At 8-17 years old]
CAIDE Dementia Risk Score [Срок оценки: At 8-17 years postpartum]
N-acetyl-β-D-glucosaminidase (NAG) [Срок оценки: At 8-17 years postpartum]
Prevalence of depression [Срок оценки: At 8-17 years postpartum]
Hyperuricemia [Срок оценки: At 8-17 years postpartum]
Hyperhomocysteinemia [Срок оценки: At 8-17 years postpartum]
Fatty liver disease [Срок оценки: At 8-17 years postpartum]
Body fat percentage: [Срок оценки: At 8-17 years postpartum]
Kutcher Adolescent Depression Scale (11-item version, KADS-11) [Срок оценки: 11-17 years old]

Критерии участия

Критерии включения

Adult patients (≥18 years old) who registered for antenatal care and delivered at Peking University Firest Hospital's obstetrics department between 2007 and 2016.
Diagnosed with gestational diabetes mellitus (GDM) during pregnancy via an oral glucose tolerance test (OGTT).
Signed informed consent.