Идёт набор NCT07101250

Preoperative Acetazolamide

Фаза IV С лечением Post Operative Pain Laparoscopic Hysterectomy Referred Pain

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Acetazolamide 500 MG Extended Release Oral Capsule, Placebo.
Кому может быть актуально: Состояния в реестре: Post Operative Pain, Laparoscopic Hysterectomy, Referred Pain. Базовые параметры: 21 лет — 65 лет · Женщины.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy

Обзор

The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.

Подробное описание

Pain control following surgery is integral to surgical success, allowing faster recovery and return to function and increasing patient satisfaction. Minimally invasive surgery, such as laparoscopy, is becoming increasingly common as it involves smaller incisions and theoretically less discomfort. However, in order to perform laparoscopy, one must insufflate the abdomen with gas in order to create space in which to operate. The most commonly used gas today is carbon dioxide, as it is highly soluble and reduces the risk of air embolism compared to room air if absorbed. A consequence of using carbon dioxide is that it is converted to carbonic acid that can be irritating to the peritoneum and specifically the diaphragm, causing referred pain to the right subscapular (shoulder) region. Multiple strategies have been undertaken to help reduce this discomfort, one of which is using acetazolamide (a carbonic anhydrase inhibitor) to help reduce peritoneal acidification. Multiple studies have demonstrated an improvement in shoulder pain following preoperative administration in laparoscopic cholecystectomy, but studies evaluating use in pelvic surgery have had mixed results. The goal of this study is to add to this understanding and determine if acetazolamide is a useful adjunct to current pain control methods in laparoscopic gynecologic surgery.

Вмешательства

Препарат Acetazolamide 500 MG Extended Release Oral Capsule
Active Drug
Препарат Placebo
Inactive Drug

Первичные конечные точки

Abdominal/pelvic pain and right subscapular pain rated on a VAS at five perioperative points [Срок оценки: From before procedure to 24 hours post procedure]
Total analgesic use postoperatively [Срок оценки: from end of procedure to 24 hours post procedure]

Критерии участия

Критерии включения

Women
Ages 21-65
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy