Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients With Dry Eye After LASIK

The development of corneal refractive surgery is rapid, but the complications are still inevitable; postoperative dry eye is one of them. Dry eye after refractive surgery will affect not only the patient's postoperative satisfaction but also the patient's postoperative visual quality, resulting in blurred vision, not lasting vision, and other problems. The occurrence of postoperative dry eye is mainly due to using anesthetics during operation; corneal nerve injury and cell apoptosis; changes in corneal curvature; postoperative medication, and so on. The patient's bad living habits may aggravate the degree of postoperative dry eye.

Diquafosol sodium is a P2Y2 receptor agonist. P2Y2 receptors are present on conjunctival and corneal epithelial cells, among others, on the ocular surface. When diquafosol sodium is used, it can activate P2Y2 receptors on these cells. This activation triggers the opening of intracellular signaling pathways that stimulate tear secretion. Normal tear secretion is important for corneal nerve repair because tears contain a variety of nutrients and growth factors. In the state of dry eye, the inflammatory factors on the ocular surface increase, and the stability of the tear film decreases. Diquafosol sodium can help to restore the stability of tear film by promoting tear secretion. A stable tear film reduces corneal nerve stimulation by inflammatory factors on the ocular surface. A large area of corneal nerves is injured during LASIK surgery, and no study has shown that diquafosol sodium has a role in nerve recovery after LASIK Hyaluronic acid (HA) lubricates, relieving dry eyes, astringent eyes, and eye fatigue. It can also flush and dilute inflammatory mediators on the ocular surface, reduce tear osmotic pressure, promote ocular surface epithelial healing, and promote ocular surface fibronectin secretion and deposition.

This study aims to compare the efficacy of 3% diquafosol and 0.1% hyaluronic acid in treating dry eye after LASIK. The observation of changes in corneal nerves and immune-inflammatory cells was added, aiming to observe the repair effect of diquafosol sodium on corneal nerves

• Conjunctivocorneal staining (CS) [Срок оценки: Baseline, week 4, week 12 and week 24]
• Tear film lipid layer (TFLL) score [Срок оценки: Baseline, week 4, week 12 and week 24]
• Corneal Sensitivity Score [Срок оценки: Baseline, week 4, week 12 and week 24]
• Tear meniscus height (TMH) [Срок оценки: Baseline, week 4, week 12 and week 24]
• Conjunctival hyperemia (RS score) [Срок оценки: Baseline, week 4, week 12 and week 24]
• Meibomian quality [Срок оценки: Baseline, week 4, week 12 and week 24]
• Meibomian gland expressibility [Срок оценки: Baseline, week 4, week 12 and week 24]
• Corneal nerves and immune/inflammatory cell change [Срок оценки: Baseline, week 4, week 12 and week 24]
• OSDI [Срок оценки: Baseline, week 4, week 12 and week 24]