Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME)

Обзор

Increased availability of high-energy dense foods has contributed to a pediatric obesity epidemic, with 23% of United States children currently presenting with the disease. How children eat contributes to both overconsumption and greater adiposity. However, it is unclear if laboratory measures of children's eating style generalize to the home environment, where children consume two thirds of their total energy. The study will 1) test if child eating styles observed in the lab generalize to more ecologically valid home environments and 2) identify aspects of home food environment that amplify obesogenic eating behaviors. We will assess laboratory and home eating styles (e.g., bite rate) in 100 prepubertal 6-9-year-old children to constrain variability in energy requirements. Children will be video-recorded while consuming identical study-provided meals at home and in the laboratory (counter-balanced order) in addition to a 'typical' meal at home. To study how adiposity relates to "obesogenic" styles of eating, gold standard dual x-ray absorptiometry will be used.

Вмешательства

• Поведенческое Meal Location
  The location at which the child will eat the experimental meal - home or lab

Первичные конечные точки

• Child body mass index [Срок оценки: Day 1]
• Food intake in grams during a standard meal [Срок оценки: Day 1 and Day 2 or 3 depending on randomization]
• Food intake in kcal during a standard meal [Срок оценки: Day 1 and Day 2 or 3 depending on randomization]
• Video coding of standard meal [Срок оценки: Day 1 and Day 2 or 3 depending on randomization]
• Food intake in grams during a snack buffet when not hungry [Срок оценки: Day 1]
• Food intake in kcal during a snack buffet when not hungry [Срок оценки: Day 1]
• Body Composition [Срок оценки: Day 1]
• Food intake in grams during a Study Meal [Срок оценки: Day 2 or 3 depending on randomization and home meal administration]
• Food intake in kcal during the Study Meal [Срок оценки: Day 2 or 3 depending on randomization and home meal administration]
• Video coding of the study meal [Срок оценки: Day 2 or 3 depending on randomization and home meal administration]

Критерии участия

Критерии включения

• children must be between the ages of 6-9 years-old
• children are of good health with no learning disabilities (e.g., ADHD, determined by parent report)
• children are not on any medications known to impact body weight, taste, food intake, behavior, or blood flow
• parents report that children like and are willing to eat study foods

Критерии исключения

• Children are not within the age requirements (<6 years old or > 9 years old)
• If children are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.
• If children don't speak English.
• If children are colorblind.
• If children have a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
• If children have a pre-existing medical condition such as type I or type II diabetes, rheumatoid arthritis, Cushing's syndrome, Down's syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, or cerebral palsy.
• If children are allergic to foods or ingredients used in the study.
• child received an X-ray in the previous year (to avoid excess radiation exposure due to the DXA scans performed in the research)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• Pennsylvania State University — State College

Публикации

• Neuwald NV, Pearce AL, Cunningham PM, Setzenfand MN, Koczwara L, Rolls BJ, Keller KL. Food switching at a meal is positively associated with change in adiposity among children at high-familial risk for obesity. Appetite. 2025 Apr 1;208:107915. doi: 10.1016/j.appet.2025.107915. Epub 2025 Feb 25. PMID 40010570
• Neuwald NV, Pearce AL, Adise S, Rolls BJ, Keller KL. Switching between foods: A potential behavioral phenotype of hedonic hunger and increased obesity risk in children. Physiol Behav. 2023 Oct 15;270:114312. doi: 10.1016/j.physbeh.2023.114312. Epub 2023 Aug 4. PMID 37543104
• Fogel A, Fries LR, McCrickerd K, Goh AT, Quah PL, Chan MJ, Toh JY, Chong YS, Tan KH, Yap F, Shek LP, Meaney MJ, Broekman BFP, Lee YS, Godfrey KM, Fong Chong MF, Forde CG. Oral processing behaviours that promote children's energy intake are associated with parent-reported appetitive traits: Results from the GUSTO cohort. Appetite. 2018 Jul 1;126:8-15. doi: 10.1016/j.appet.2018.03.011. Epub 2018 Mar PMID 29551400
• Fogel A, Goh AT, Fries LR, Sadananthan SA, Velan SS, Michael N, Tint MT, Fortier MV, Chan MJ, Toh JY, Chong YS, Tan KH, Yap F, Shek LP, Meaney MJ, Broekman BFP, Lee YS, Godfrey KM, Chong MFF, Forde CG. A description of an 'obesogenic' eating style that promotes higher energy intake and is associated with greater adiposity in 4.5year-old children: Results from the GUSTO cohort. Physiol Behav. 2017 PMID 28213204
• Fogel A, Goh AT, Fries LR, Sadananthan SA, Velan SS, Michael N, Tint MT, Fortier MV, Chan MJ, Toh JY, Chong YS, Tan KH, Yap F, Shek LP, Meaney MJ, Broekman BFP, Lee YS, Godfrey KM, Chong MFF, Forde CG. Faster eating rates are associated with higher energy intakes during an ad libitum meal, higher BMI and greater adiposity among 4.5-year-old children: results from the Growing Up in Singapore Toward PMID 28462734
• Pearce AL, Cevallos MC, Romano O, Daoud E, Keller KL. Child meal microstructure and eating behaviors: A systematic review. Appetite. 2022 Jan 1;168:105752. doi: 10.1016/j.appet.2021.105752. Epub 2021 Oct 16. PMID 34662600
• Pearce AL, Adise S, Roberts NJ, White C, Geier CF, Keller KL. Individual differences in the influence of taste and health impact successful dietary self-control: A mouse tracking food choice study in children. Physiol Behav. 2020 Sep 1;223:112990. doi: 10.1016/j.physbeh.2020.112990. Epub 2020 Jun 4. PMID 32505786

Идентификаторы

NCT: NCT07095166 · STUDY00026981

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗