Perspectives on Antibiotics and Tracking Symptoms in Children

This is a mainly observational study looking at the feasibility and acceptability of the study instruments and procedures to be incorporated into an upcoming clinical trial. Parents/guardians will be asked to provide feedback on study procedures and questionnaires. The study will also assess feasibility and acceptability of a shorter course of antibiotic therapy (i.e. stopping earlier) to be tested in the upcoming clinical trial (noting that no antibiotics will be stopped early in this study).

The study will also include a clinical trial component. A small number of participants will be invited to wear a Garmin Smartwatch to collect data about heart rate, heart rate variability, skin temperature and sleep and activity levels. Data collected with the Garmin Smartwatch will be compared to parent reported symptoms (collected via the questionnaires noted above) in order to determine the level of agreement.

All study surveys and Garmin data will be collected through the WeGuide platform. WeGuide is a patient engagement software platform that allows for enrolment, consent, and data collection (via questionnaires/surveys and from the Garmin Smartwatches) through a singular platform.

Study participants will be children (4-17 years of age) who present to the RCH with uncomplicated bacterial infections and are prescribed oral antibiotics (either immediately or as switch from IV antibiotics after transfer to HITH) as standard of care, to assess their and their parents' satisfaction with the study instruments employed in this study, in preparation for the upcoming clinical trial.

WeGuide and Garmin are supporting the PATSy study through the WeGuide and Garmin Health Grant for Digital Health and Wellbeing. The grant includes use of the WeGuide platform and the Garmin Trackers. WeGuide and Garmin have no role in recruitment, data collection, data analysis or publication of the study.

• Agreement between reports of fever recorded by the Garmin Tracker versus the daily questionnaire - measured using Cohen's kappa coefficient [Срок оценки: Baseline to Day 10]
• Agreement between reports of sleep quality recorded by the Garmin Tracker versus the daily questionnaire - measured using Cohen's kappa coefficient [Срок оценки: Baseline to Day 10]
• Agreement between reports for activity level recorded by the Garmin Tracker versus reports of daytime lethargy/tiredness in the daily questionnaire [Срок оценки: Baseline to Day 10]
• Number of participants who re-start antibiotics within 28 days of antibiotic commencement as reported in study-specific questionnaire [Срок оценки: Day 28]
• Number of participants who are still unwell at Day 28 as reported in study-specific questionnaire [Срок оценки: Day 28]
• Number of participants who finished complete course of antibiotics as reported in study-specific questionnaire [Срок оценки: Day 14]
• Number of reported doses of antibiotics administered versus doses prescribed as reported in study-specific questionnaire [Срок оценки: Day 10]
• Number of participants who report stopping antibiotics early due to resolution of symptoms - as reported on the study-specific questionnaire [Срок оценки: Day 14]
• Reason for stopping antibiotics early as reported on study-specific questionnaire [Срок оценки: Day 14]