Effects of Transcranial Direct Current Stimulation After Short-term Immobilization on Motor Learning and Hand Function in Healthy Young Adults

Обзор

The purpose of the study is to investigate the effects of short-term braking on the motor learning and fine motor skills of healthy adults, and to analyze whether transcranial direct current stimulation can alleviate the effects of braking on motor learning and fine motor skills.

Подробное описание

The purpose of the study is to investigate the effects of 16-hour short-term immobilization on the motor learning and fine motor skills of healthy adults, and to analyze whether transcranial direct current stimulation intervention can alleviate the effects of immobilization on motor learning and fine motor skills.

Вмешательства

• Процедура transcranial direct current stimulation
  The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 5 cm).The stimulation intensity will be set at 2 mA. The stimulation will last for 20 minutes, with a 10 s fade-in period at the start and a 10-s fade-out period at the end of stimulation. The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center
• Устройство sham transcranial direct current stimulation
  The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 5 cm).The stimulation intensity will be set at 2 mA. The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center of the forehead for 20 minutes. However, there will be current only during the first 10 seconds and the last 10 seconds.
• Процедура immobilization
  The researchers will use an upper limb fixation splint to fix the right upper limb of the participants, with the elbow joint flexed at 90 degrees, to ensure that all movements of the wrist, metacarpophalangeal joints, proximal interphalangeal joints, and interphalangeal joints are completely restricted. To avoid discomfort caused by the splint, soft bandages will be wrapped around the hand, and the splint will be adjusted to fit the shape of the hand. Ensure that the fingertips are visible to en

Первичные конечные точки

• Sequence Reaction Time Task [Срок оценки: Baseline; after one week]

Вторичные конечные точки (2)

• Purdue Pegboard Test [Срок оценки: Baseline; after one week]
• Reach and grasp action test [Срок оценки: Baseline; after one week]

Критерии участия

Критерии включения

• (1) age between 18 and 25 years;
• (2) normal or corrected-to-normal vision;
• (3) right-handedness.

Критерии исключения

• (1) with history of pregnancy, cardiovascular disease, other physical impairments or illnesses;
• (2) with personal or family history of mental illness;
• (3) implanting any internal or external medical devices;

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Четверное слепое

Основная цель

Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT07089056 · 2023145H

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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