Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients

Обзор

This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.

Подробное описание

The study titled "Combined Effect of Aerobic and Resistance Exercise in Non-Ischemic Dilated Cardiomyopathy Patients" by Arooj Fatima investigates how integrating both aerobic and resistance exercises impacts patients suffering from NIDCM, a condition marked by left ventricular dysfunction and reduced exercise tolerance. Through a randomized clinical trial involving 66 patients divided into two groups-one receiving both aerobic and resistance training and the other only aerobic training-the study evaluated changes in ejection fraction, VO₂ max, dyspnea, and functional independence over six weeks. Significant improvements were observed within both groups across all measured outcomes, including increased exercise capacity, better functional independence, and reduced blood pressure and dyspnea levels. However, no statistically significant difference was found between the two groups, indicating that while both exercise regimens are beneficial, the combined approach did not yield superior results within the study's timeframe. The research highlights the value of structured exercise in improving cardiovascular and functional outcomes in NIDCM patients and recommends longer, more varied studies to further explore these benefits.

Вмешательства

• Поведенческое Combined Aerobic and Resistance Exercise
  Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.
• Поведенческое Aerobic Exercise Only
  Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Первичные конечные точки

• Functional Independence Measure (FIM) questionnaire [Срок оценки: Baseline and 6 weeks]
• VO₂ Max (Maximum Oxygen Consumption) [Срок оценки: Baseline and 6 weeks.]

Вторичные конечные точки (2)

• Modified Borg Dyspnea Scale [Срок оценки: Baseline and 6 weeks.]
• Blood Pressure (Systolic and Diastolic) [Срок оценки: Baseline and 6 weeks.]

Критерии участия

Критерии включения

• Both male and female Age 40 to 60
• Left ventricular ejection fraction <50%

Критерии исключения

• Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.
• Neuromuscular diseases such as stroke, Parkinson.
• Underlying pulmonary disease
• Impaired cognitive function (14)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Пакистан · 1 центр

• Arjumand — Lahore

Идентификаторы

NCT: NCT07062874 · REC/RCR&AHS/24/0359

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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