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Идёт набор NCT07049224

The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals

Без фазы С лечением Muscle Protein Synthetic Response to Protein

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Meat diet, Plant diet.
Кому может быть актуально
Состояния в реестре: Muscle Protein Synthetic Response to Protein. Базовые параметры: 65 лет — 85 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Нидерланды
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function. Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.

Вмешательства

  • Другое Meat diet
    Participants will be subjected to a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise.
  • Другое Plant diet
    Participants will be subjected to a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise.

Первичные конечные точки

  • Integrated muscle protein synthesis rate in rested leg [Срок оценки: The 2 intervention periods over which FSR is determined will each last 10 days]
Вторичные конечные точки (7)
  • Integrated muscle protein synthesis rate in exercised leg [Срок оценки: The 2 intervention periods over which FSR is determined will each last 10 days]
  • Blood glucose [Срок оценки: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood insulin [Срок оценки: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood lipid profile [Срок оценки: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood inflammatory markers [Срок оценки: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood amino acid profile [Срок оценки: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood pressure [Срок оценки: The 2 intervention periods after which the blood pressure is determined will each last 10 days]

Критерии участия

Критерии включения

  • Male or female sex
  • Aged between 65 and 85 y inclusive
  • BMI between 18.5 and 30 kg/m2 inclusive

Критерии исключения

  • Not willing to consume meat/animal-based products during the study period
  • Any food allergies (e.g. milk, gluten, etc.)
  • Participating currently or in the 3 months prior to the study in a structured progressive exercise program.
  • Smoking
  • History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the study team and responsible physician)
  • Diagnosed with phenylketonuria (PKU)
  • Donated full blood 3 months prior to test day
  • Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the study team and responsible medical doctor.
  • Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
  • Fasting blood glucose >7 mmol/L

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Перекрёстный дизайн
Маскирование
Простое слепое
Основная цель
Фундаментальное исследование

Центры проведения

Нидерланды · 1 центр
  • Maastricht University Medical Centre+ — Maastricht

Идентификаторы

NCT: NCT07049224 · METC 24-025 · NL87069.068.24

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗