The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

Обзор

This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.

Подробное описание

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.

The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.

Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.

Вмешательства

• Другое Renal resistive index
  It will be measured with ultrasound-Doppler using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or inter-lobar artery will be localized, and three successive Doppler measurements at different positions in the kidney (high, middle, and low) will be performed. The average value for each kidney will be taken. The rena
• Другое Renal Artery Pulsatility Index
  It will be measured using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney, the interlobular artery will be located using color Doppler mode, and the velocity of the interlobular arteries will be assessed in one or two kidneys. The Renal Artery Pulsatility Index (RAPI) will be calculated as follows: RAPI = \[(peak systolic velocity) - (end diastolic velocity)\] /average velocity
• Другое Urinary oxygen tension (PUO2)
  Urinary oxygen tension (PUO2) will be measured preoperatively (baseline), postoperatively just after intensive care unit admission, 12 hours after surgery, and then once daily for 7 days.

Первичные конечные точки

• Number of cases developed acute kidney injury [Срок оценки: 7 days after the procedure]

Вторичные конечные точки (5)

• Length of intensive care unit stay [Срок оценки: 7 days after the procedure]
• Length of hospital stay [Срок оценки: 7 days after the procedure]
• Need for renal replacement therapy [Срок оценки: 7 days after the procedure]
• Number of patients developed chronic kidney disease [Срок оценки: 7 days after the procedure]
• Mortality rate [Срок оценки: 7 days after the procedure]

Критерии участия

Критерии включения

• Age above 21 years.
• Both sexes.
• Undergoing elective on-pump cardiac surgery.

Критерии исключения

• Patients with chronic kidney disease.
• Patients with any renal pathology or anatomic kidney abnormalities.
• Patients on renal replacement therapy.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Египет · 1 центр

• Tanta University — Tanta

Идентификаторы

NCT: NCT07037485 · 36265MD279/9/24

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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