Fighting Addictions, Improving Lives: COmprehensive Drug Rehabilitation With Music

Substance use disorder (SUD) is associated with a high global burden of disease: 4.2% of all disability-adjusted life years lost (DALYs, a combined measure of years of life lost and years lived with disability) are due to alcohol and 1.3% due to illicit drugs. Remarkably, approved pharmacological treatment options are not available for most SUDs, and non-pharmacological approaches are still the backbone of SUD treatment.

Music therapy (MT) is a non-pharmacological intervention recommended i some SUD guidelines. In MT, defined as the clinical and evidence-based use of music interventions to accomplish individualized goals within a therapeutic relationship by a credentialed professional, a music therapist uses music and musical activities to support individuals or groups in reaching specific therapeutic goals. This includes activities such as music listening and active music making, which are tailored to participants' cultural context and individual needs.

The FALCO-trial is a parallel 3-arm assessor- and statistician-blinded pragmatic multinational randomized clinical trial. The interventions of interest in the trial (AMG, MLG) are non-pharmacological psychosocial interventions. Both AMG and MLG will be conducted by appropriately qualified music therapists, in groups, with weekly sessions lasting up to 90 minutes. Participants will continue to receive TAU as offered locally.

The primary objective of the study is to determine effects of AMG and MLG versus TAU on addiction severity in people with SUD at one year after randomization.

• Recovery assessed by the Substance Use Recovery Evaluator (SURE) [Срок оценки: Baseline, 1 year, 2 years.]
• Substance use severity assessed by Drug Disorder Identification Test (DUDIT-C) [Срок оценки: Baseline, 3 months, 1 year, 2 years.]
• Substance use severity assessed by Alcohol Use Disorder Identification Test (AUDIT-C) [Срок оценки: Baseline, 3 months, 1 year, 2 years.]
• Quality of life assessed by EuroQol (EQ-5D) [Срок оценки: Baseline, 1 year, 2 years.]
• Depressive symptoms assessed by the Montgomery-Åsberg Depression Rating Scale (MADRS) [Срок оценки: Baseline, 1 year, 2 years.]
• Attrition assessed by clinicians [Срок оценки: 3 Months, 1 year, 2 years.]
• Adverse effects assessed by clinicians [Срок оценки: 3 months, 1 year, 2 years.]
• Employment monitored by public records [Срок оценки: 10 years.]
• Hospitalisation monitored by health records [Срок оценки: 10 years.]
• Criminal record monitored by public records [Срок оценки: 10 years.]
• Survival monitored by public records [Срок оценки: 10 years.]
• Motivation for change assessed by the Importance, Confidence, Readiness Ruler (ICR) [Срок оценки: 1 week, 3 months, 1 year.]